metformin

Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂，具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制，常用于 2 型糖尿病的研究。

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 是一种 AMPK 激活剂，具有血脑屏障渗透性。Metformin hydrochloride 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制，常用于 2 型糖尿病的研究。

Syrosingopine 是 MCT1和 MCT4双重抑制剂，对 MCT4 的效力高 60 倍，可防止乳酸和 H+ 流出。Syrosingopine是可口服抗高血压药物，联合二甲双胍具有研究癌症疾病的潜力。

BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂，可刺激 Ampk 依赖性信号传导。它促进线粒体分裂，促进自噬并提高肝脏胰岛素敏感性。

Linagliptin mixture with metformin is used for the treatment of type 2 diabetes.

Metformin glycinate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.

Metformin icosapent is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.

Metformin hydroxy analog 2, an oxidation product of the biguanide metformin (1), represents a chemically transformed variant of the original compound, showcasing a modified molecular structure through the process of oxidation.

Metformin embonate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.

Metformin orotate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.

Itasetron hydrochloride monohydrate is a potent 5HT-3 receptor antagonist.

Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator.

Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) 是 Metformin 的一种氘代化物，可用于研究 Metformin 在体内的代谢，常作为Metformin的内标。

Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。

IM156 (HL156A; HL271 acetate) 是衍生自二甲双胍的化合物，是一种强效的，具有口服活性的AMPK 激活剂。IM156 在动物模型中可缓解与年龄相关的认知下降。IM156 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂，可用于实体肿瘤的研究。

INCB13739 是一种具有口服活性、选择性和高效性的 11β- 羟类固醇脱氢酶 1（11β-HSD1) 抑制剂。INCB13739 可改善二甲双胍单药治疗控制不佳的 2 型糖尿病患者的高血糖，可用于研究高脂血症和高甘油三酯血症。

HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.

LCC-12 FA 是一种由二甲双胍组成的二聚体，通过靶向线粒体铜 （ii） 从而诱导 NAD（H） 池减少。LCC-12 FA 可减少细菌和病毒感染小鼠模型中的炎症，可用于研究代谢疾病。

Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg L against Staphylococcus aureus strains[1][2].