interferon, a 2

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) 是细胞天然免疫中第二信使，在 DNA 结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP sodium 可与 STING 结合形成二聚体，诱导 IFN-β 及其他细胞因子的产生和表达。

Inosine pranobex (Delimmun) 是一种免疫增强剂，它是一种广谱抗病毒剂，用于 HIV 感染。

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是细胞天然免疫中第二信使，在DNA结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP 可与 STING 结合形成二聚体，诱导干扰素-β（IFN-β）及其他细胞因子的产生和表达。

PCC0208018 is a novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1) programmed cell death-ligand 1 (PD-L1) binding and not directly affecting tumor cell viability in vitro.

cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使，通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子（STING），启动信号级联，进而导致I型干扰素及其他免疫介质的生成。

PROTAC STING Degrader-2 是针对 Stimulator of interferon genes (STING) 的蛋白质降解剂，具有DC50为0.53 μM的活性。它通过同时与STING蛋白和E3泛素连接酶共价结合，诱导STING蛋白的降解。该化合物可用于研究STING在自身炎症和自身免疫性疾病中的作用。

BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT

Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM).

5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar, K., Zhang, Z., Teles, R.M., et al.DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseNat. Immunol.13(12)1155-1161(2012) 3.Woodward, J.J., Iavarone, A.T., and Portnoy, D.A.c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon responseScience328(5986)1703-1705(2010) 4.Witte, C.E., Whiteley, A.T., Burke, T.P., et al.Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infectionmBio4(3)e00282-00213(2013) 5.Fahmi, T., Port, G.C., and Cho, K.H.c-di-AMP: An essential molecule in the signaling pathways that regulate the viability and virulence of gram-positive bacteriaGenes (Basel)8(8)197(2017)

Peginterferon alfa-2b 是一种免疫调节剂。Peginterferon alfa-2b 是一种共价连接 PEG 的重组 alfa-2b 干扰素。Peginterferon alfa-2b 减少HIV 中的病毒 DNA。Peginterferon alfa-2b 可用于黑色素瘤的研究。

CDN-A为一种环二核苷酸，主要用于抗体-活性分子偶联物(ADC)的合成。作为先天免疫及适应性免疫反应的关键激活剂，环状二核苷酸能由内源性外来DNA或侵入性细菌病原体生成，在人体内通过促进干扰素基因表达激活先天免疫系统。

Dazostinag (TAK-676 free base) 为干扰素基因刺激剂 (STING) 蛋白的激动剂，展现出抗肿瘤活性。它能作为有效载荷 (payload) 用于合成抗体偶联活性分子 (ADC) 的构建。

Cepeginterferon alfa-2b是一种聚乙二醇化干扰素, 其聚乙二醇基由分子量为20 kDa的PEG构成。该化合物广泛应用于丙型肝炎病毒(HCV)、真性红细胞增多症(PV)和原发性血小板增多症(ET)等疾病的研究中。

STINGagonist-22 (CF501) 是一种有效的非核苷酸STING 激动剂。STINGagonist-22 是一种佐剂，通过激活STING 来诱导 I 型干扰素 (IFN-I) 反应和促炎细胞因子的产生。STINGagonist-22 可用作增强原始蛋白疫苗的佐剂，产生有效、广泛和长期的免疫保护。STINGagonist-22 可用于 SARS-CoV-2 变异和 sarbecovirus 疾病研究。

JMS-175-2，一种具有3.8 μM IC50的高效BRCC36异肽酶复合物(BRISC)抑制剂，对于I型干扰素介导的疾病具有显著影响。

93-O17S is a chalcogen-containing cationic lipidoid.1It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been used for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes (STING) activation in a B16 F10 murine melanoma model.2 1.Li, Y., Yang, T., Yu, Y., et al.Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteinsBiomaterials178652-662(2018) 2.Chen, J., Qiu, M., Ye, Z., et al.In situ cancer vaccination using lipidoid nanoparticlesSci. Adv.7(19)eabf1244(2021)