filaments

NP-G2-044 是fascin 蛋白抑制剂，具有口服活性，IC50值约为 2 μM。它可阻断肿瘤转移并增强抗肿瘤免疫应答。

Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽，是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，对 F-肌动蛋白的 Kd 值为 15 nM。

Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) 是肌动蛋白掺入细丝的有效抑制剂。

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2]. Animal Model: Rats.[2] [1]. Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. [2]. Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6.

Swinholide A 是可从海绵中提取的聚酮化合物，可于肌动蛋白结合，使肌动蛋白二聚化，Kd 约为 50 nM。Swinholide A 是一种细胞毒素，可稳定肌动蛋白二聚体并切断肌动蛋白丝。Swinholide A 具有抗真菌 (antifungal)活性，可破坏细胞的肌动蛋白细胞骨架。

Sinoporphyrin sodium significantly suppressed cell proliferation, promoted early apoptotic response, triggered collapse of F-actin filaments and inhibited cell migration. Sinoporphyrin sodium potentially a treatment for cancer. Sinoporphyrin sodium is als

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

IMM-01 是一类新型的哺乳动物透明 (mDia) 相关形式的小分子激动剂，其作用于 Rho GTPase 下游以组装肌动蛋白丝，并与微丝组织在迁移和不对称分裂过程中建立和维持细胞极性. GTP 结合的 Rho 通过破坏 DID 和 DAD 自动调节结构域之间的相互作用来激活 mDia 家族成员，从而释放 FH2 结构域以调节肌动蛋白和微管动力学。

Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong

Phalloidin-retramethylrhodamine conjugate is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. It can be used to localize actin filaments in living or fixed cells, as well as for visualizing individual actin filaments in vitro.