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Search Results for " duplex dna "
Targets Recommended: DNA Alkylation Antibiotic ADC Cytotoxin

6

抑制剂 & 化合物

6

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T11120 Duocarmycin TM

DNA Alkylation; Antibiotic; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; DNA Damage/DNA Repair; Microbiology/Virology
Duocarmycin TM 是一种有抗肿瘤活性的抗生素,也是一种 DNA 烷化剂。
T23133 Pentamidine

Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal Metabolism; Microbiology/Virology
Pentamidine 是抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。
T11118 Duocarmycin SA

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.
T11338 Furamidine

DB75,NSC 305831

Others Others
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and ...
T81640 NSC15520

Others Others
NSC15520是一种小分子RPA抑制剂,特异性结合RPA的N端DNA结合域(DBD),阻断其与p53或RAD9的相互作用。它还能够抑制双链DNA(dsDNA)寡核苷酸的螺旋不稳定性,影响DNA复制、修复、重组及损伤反应信号。
T37218 N-methyl Mesoporphyrin IX

N-methyl Mesoporphyrin IX 是广泛使用的 G-quadruplex DNA 特异性荧光结合剂,能有效监测 Aβ 纤颤。N-methyl Mesoporphyrin IX 对 G-四链体 DNA 敏感,对双链体、三链体和单链形式的 DNA 没有反应。N-methyl Mesoporphyrin IX 需通过与 Aβ 组装体堆叠才能发出强荧光。同时 N-methyl Mesoporphyrin IX 是一种原位抑制剂,是体外和细胞内 Aβ 淀粉样蛋白生成的非原位监测器。

化合物

Duocarmycin TM
Cat.No: T11120
Synonym:
Target: DNA Alkylation, Antibiotic, ADC Cytotoxin
Pentamidine
Cat.No: T23133
Synonym:
Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal
Duocarmycin SA
Cat.No: T11118
Synonym:
Target: Others, ADC Cytotoxin
Furamidine
Cat.No: T11338
Synonym: DB75,NSC 305831
Target: Others
NSC15520
Cat.No: T81640
Synonym:
Target: Others
N-methyl Mesoporphyrin IX
Cat.No: T37218
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPH-01241 TOP1 Protein, Human, Recombinant (His & Myc)

DNA topoisomerase 1,TOP1,DNA topoisomerase...

Human Baculovirus Insect Cells
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates a...
TMPH-00611 DNA helicase II Protein, E. coli, Recombinant

mutU,DNA 3'-5' helicase II,DNA helicase II...

E. coli E. coli
A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA. DNA helicase II Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 82.0 kDa and the acce...
TMPH-00665 RecG Protein, E. coli O157:H7, Recombinant (His & SUMO)

ATP-dependent DNA helicase RecG,recG

E. coli E. coli
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (CsdR) and R-loop formation.
TMPH-01270 TRAIP Protein, Human, Recombinant (His)

E3 ubiquitin-protein ligase TRAIP,TRAF-interacting protein,T...

Human E. coli
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPY-01383 PRMT6 Protein, Human, Recombinant (His & Flag)

protein arginine methyltransferase 6,HRMT1L6

Human HEK293 Cells
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H...
TMPH-01239 XPC Protein, Human, Recombinant (His)

Xeroderma pigmentosum group C-complementing protein,p125,XPC...

Human E. coli
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein i...

重组蛋白

TOP1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01241
Species: Human
Expression System: Baculovirus Insect Cells
DNA helicase II Protein, E. coli, Recombinant
Cat.No: TMPH-00611
Species: E. coli
Expression System: E. coli
RecG Protein, E. coli O157:H7, Recombinant (His & SUMO)
Cat.No: TMPH-00665
Species: E. coli
Expression System: E. coli
TRAIP Protein, Human, Recombinant (His)
Cat.No: TMPH-01270
Species: Human
Expression System: E. coli
PRMT6 Protein, Human, Recombinant (His & Flag)
Cat.No: TMPY-01383
Species: Human
Expression System: HEK293 Cells
XPC Protein, Human, Recombinant (His)
Cat.No: TMPH-01239
Species: Human
Expression System: E. coli
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