dna mutation

Chromium picolinate 具有降低胰岛素抵抗的作用，对 2 型糖尿病具有潜在的研究价值。

MU1409 是一种MRE11核酸酶抑制剂，其IC50为12.1 μM。除此之外，MU1409 对FEN1和EXO1也有抑制作用，IC50分别为24.2 μM和176.4 μM。MU1409 能影响细胞内DNA修复，阻止BRCA2缺陷细胞中停滞复制叉的降解，这为BRCA2突变相关的癌症研究提供了潜力。

Symphytine is a natural inducer of hepatic tumors. Symphytine interacts with DNA in liver endothelial cells and hepatocytes, resulting in DNA damage, mutation induction, and cancer development.

9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found in O. maculataand has anticancer activity.It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 μM, respectively).

MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12 13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation and DNA damage repair gene expression. Consistent with its effect on DNA damage repair gene expression, MFH290 augments the antiproliferative effect of the PARP inhibitor olaparib.

Aristolochic acid B (Aristolochic Acid II) 是一种来自马兜铃科分类群的天然产物，是马兜铃酸的主要成分之一。马兜铃酸是诱变剂和致癌物质，Aristolochic acid B (Aristolochic Acid II) 在体内能表现出比 Aristolochic acid I 更大的致癌风险。