d18:0

N,N-dimethyl Sphinganine (d18:0) is a sphingolipid that increases during development ofL. donovanipromastigotes.1 1.Silva, A.M., Cordeiro-da-Silva, A., and Coombs, G.H.Metabolic variation during development in culture of Leishmania donovani promastigotesPLoS Negl. Trop. Dis.5(12)e1451(2011)

D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver.

C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 164989-36-0。

C6 dihydro Ceramide (d18:0/6:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 171039-13-7。

C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 2377379-54-7。

C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in the skin of patients with lesional atopic dermatitis.[3]

C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squamous carcinoma cells in vitro.[4] C24 dihydro Ceramide levels are also increased in INS-1 β-cells incubated with glucose and palmitate.[5]

(±)-2'-hydroxy Ceramide (d18:0/18:0)' 为一种鞘磷脂，能够自 ADP 刺激下的哺乳动物血小板中提取。

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 190249-36-6。

C17 dihydro Ceramide (d18:0/17:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 1388156-40-8。

C18 dihydro Ceramide (d18:0/18:0) (Standard) 是一种可用于分析的标准物质，通常用作 C18 dihydro Ceramide (d18:0/18:0) 的研究和分析中参考的标准样品。C18 dihydro Ceramide 是一种具有生物活性的鞘脂类物质，也是 C18 鞘氨醇（缺乏 4,5-反式双键）的原始合成物质。

C24 dihydro Ceramide (d18:0/24:0) (Standard) 是一种可用于分析的标准物质，通常用作 C24 dihydro Ceramide (d18:0/24:0) 的研究和分析中参考的标准样品。C24 dihydro Ceramide 是一种鞘脂类物质，存在于人类皮肤的角质层中。与男性皮脂相比，女性皮脂中的 C24 dihydro Ceramide 含量更高。

14:0 Dihydro SM (d18:0/14:0) 是一种鞘磷脂。

Sphingomyelin (d18:1/12:0)为一种具调节细胞信号传导功能的极性脂质，它在细胞膜中扮演着至关重要的角色，不仅影响膜的流动性和稳定性，还参与脂质代谢并促进神经细胞生长。此外，Sphingomyelin (d18:1/12:0)在神经系统的功能发育中也具有不可或缺的作用。

GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) 是一种鞘糖脂，具有在帕金森病和路易体痴呆研究中的潜在应用价值。

C16 Ganglioside GM1 (d18:1/16:0) (C16-GM1) ammonium 是神经节苷脂家族的一个成员，含有饱和的 C16:0 酰基链。它作为 Cholera toxinB 亚基的功能性受体，但在胞吞转运和逆行转运途径中的效率较低。C16 Ganglioside GM1 (d18:1/16:0) ammonium 可用于研究腹泻疾病。

C16 Ceramide (Cer) (d18:1(14Z)/16:0) 是一种由长链鞘氨醇（d18:1）和棕榈酸（C16:0）组成的鞘氨醇神经酰胺，是重要的脂质信号分子之一，与细胞凋亡相关。C16 型神经酰胺尤其在细胞周期阻滞、细胞死亡及胰岛素信号抑制中发挥作用。

C24 Ceramide (d18:1(14Z)/24:0) 是一种神经酰胺，应用于肥胖研究。

Cer(d18:2_22:0) 是一种可能用于识别异染性脑白质营养不良疾病的生物标志物。

C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.

C16 Sphingomyelin (d18:1/16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物，可用于研究生物膜的活性。

C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in men with prostate cancer.

C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]

C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.