购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空
筛选
已筛选:全部清除
TargetMol | Tags 通过 靶点 筛选
  • Akt
    (4)
  • Apoptosis
    (4)
  • Antifection
    (3)
  • Autophagy
    (3)
TargetMol | Tags 通过 货期 筛选
  • 现货
    (16)
  • 5日内发货
    (10)
  • 20日内发货
    (3)
  • 35日内发货
    (4)
抑制剂&激动剂
细分筛选
搜索结果
TargetMol产品目录中 "colon carcinoma"的结果
筛选
搜索结果
TargetMol产品目录中 "

colon carcinoma

"的结果
  • 抑制剂&激动剂
    48
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    10
    TargetMol | Recombinant_Protein
  • 天然产物
    22
    TargetMol | Natural_Products
  • 同位素
    2
    TargetMol | Isotope_Products
  • 检测抗体
    1
    TargetMol | Antibody_Products
  • Aliskiren hemifumarate
    阿利克仑半富马酸盐, SPP 100, CGP60536B, CGP 60536
    T1520173334-58-2
    Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂,IC50为1.5 nM,具有抗高血压活性。
    • ¥ 355
    In stock
    规格
    数量
  • EIPA
    MH 12-43, L593754
    TQ01571154-25-2
    EIPA (L593754) 是一种 TRPP3 channel 抑制剂 (IC50=10.5 μM),也是 Na+ H+交换 (NHE) 的抑制剂。EIPA 可以抑制巨胞饮作用,促进自噬,可用于炎症和肿瘤研究。
    • ¥ 258
    In stock
    规格
    数量
  • 5-ALA benzyl ester hydrochloride
    Benzyl-ALA hydrochloride
    T19147163271-32-7In house
    5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) 是一种原卟啉前体,可用作光检测器。5-ALA benzyl ester hydrochloride 在结肠癌细胞系中可以诱导原卟啉 IX (PPIX) 的积聚。
    • ¥ 153
    In stock
    规格
    数量
  • Silibinin
    水飞蓟宾 A, 水飞蓟宾, Silymarin I, Silybin, Silibinin A
    T166022888-70-6
    Silibinin (Silybin) 是水飞蓟的主要活性成分,具有抗癌和化疗预防作用,能抑制细胞增殖和迁移。
    • ¥ 270
    In stock
    规格
    数量
  • 2'-Deoxyinosine
    Guanine deoxyriboside, 2'-脱氧肌苷
    T1709890-38-0
    2'-Deoxyinosine (Guanine deoxyriboside) 具有 抑制人癌细胞株生长的活性,并发现其与嘌呤核苷磷酸化酶缺乏有关。
    • ¥ 178
    In stock
    规格
    数量
  • PFK-015
    PFK15, PFK 015
    T24554382-63-2
    PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。
    • ¥ 197
    In stock
    规格
    数量
  • PF-04217903
    T2676956905-27-4
    PF04217903 是一种高效的、 ATP 竞争性的c-Met 激酶抑制剂(Ki=4.8 nM),相对于 208 个激酶,PF04217903 显示出 1000 倍以上的选择性。它抗血管生成作用。
    • ¥ 233
    In stock
    规格
    数量
  • Rotundic acid
    铁冬青酸, Rutundic acid
    T5S050620137-37-5
    Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物,具有抗炎和保护心脏的能力。它可通过 AKT mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。
    • ¥ 186
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Ganoderic acid D
    灵芝酸D, 灵芝酸 D
    T5S1133108340-60-9
    Ganoderic acid D 是高度氧化的四环三萜,是灵芝的主要活性成分,可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程,包括结肠癌细胞中的葡萄糖摄取,乳酸、丙酮酸和乙酰辅酶的产生。
    • ¥ 649
    In stock
    规格
    数量
  • AK-1
    T5618330461-64-8
    AK-1是一种特异性有效和细胞可渗透的SIRT2抑制剂,其IC50值为 12.5 μM。它可防止阿尔茨海默病模型中的海马神经退行性变并诱导结肠癌细胞中的细胞周期停滞。
    • ¥ 113
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Tubulin polymerization-IN-47
    T776512834087-62-4
    Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂,具有抗肿瘤活性,对神经母细胞瘤癌细胞增殖具有抑制作用,对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。
    • ¥ 325
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Cinnamamide
    NSC 32953
    T20050621-79-4
    Cinnamamide is an amide of trans-cinnamic acid and a metabolite of Streptomyces. It also reduced tumor weight in a mouse model of C26 murine colon carcinoma, in vivo.
    • ¥ 528
    5日内发货
    规格
    数量
  • PD-1/PD-L1-IN-52
    T200724
    PD-1 PD-L1-IN-52 (Compound Ⅲ-5) 作为一种具有口服活性的PD-1 PD-L1抑制剂,能有效阻断PD-1与PD-L1的相互作用,其IC50值为109.9 nM。在表达人源PD-1的MC38结肠癌细胞系的C57BL 6小鼠的异种移植模型中,PD-1 PD-L1-IN-52显示出显著的抗肿瘤效果,肿瘤生长抑制率(TGI)达到49.6%。
    • 待询
    规格
    数量
  • CHI-KAT8i5
    T2044102839860-29-4
    CHI-KAT8i5 是一种高选择性的KAT8抑制剂,具有 19.72 μM 的 KD。它能以剂量依赖性方式引发凋亡 (Apoptosis),并抑制食管鳞状细胞癌、结肠癌、黑色素瘤、胃癌、非小细胞腺癌及肝癌的肿瘤生长。
    • 待询
    10-14周
    规格
    数量
  • BET/Aurora kinase-IN-1
    T2050732674064-32-3
    BET Aurora kinase-IN-1 (Compound 38) 是一种双效BET Aurora kinase抑制剂。其对多种肿瘤细胞系展现抗增殖活性,并在肾细胞癌和结肠癌的异种移植模型中表现出显著的抗肿瘤效果,肿瘤生长抑制 (TGI) 分别达到45.99%和53.06%。
    • 待询
    10-14周
    规格
    数量
  • PHPS1
    PHPS-1, PHPS 1
    T28410314291-83-3
    PHPS1 是 Shp2的选择性抑制剂,对 Shp2,Shp2-R362K,Shp1,PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73,5.8,10.7,5.8 和 0.47 μM。
    • ¥ 378
    In stock
    规格
    数量
  • Eicosapentaenoyl 1-propanol-2-amide
    T364261638355-66-4
    Monoacylglycerols (MAGs) of ω-3 polyunsaturated fatty acids have diverse physiological and health effects. In particular, MAGs containing docosahexaenoic acid or eicosapentaenoic acid have anti-proliferative properties against colon and lung cancer cell lines. Eicosapentaenoyl 1-propanol-2-amide is an EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells, producing 98.4% growth inhibition when applied at 3 μM. It is an analog of eicosapentaenoyl ethanolamide , a natural N-acylethanolamide that impacts aging and inflammation.
    • 待估
    35日内发货
    规格
    数量
  • 1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
    T36452799268-65-8
    1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2 EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2- - dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.
    • 待估
    35日内发货
    规格
    数量
  • Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
    T366271234494-75-7
    Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.
    • ¥ 457
    待询
    规格
    数量
  • Chromomycin A2
    T368466992-70-7
    Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It also inhibits the growth of human SGC7901 gastric cancer, HepG2 hepatocellular carcinoma, A549 lung epithelial adenocarcinoma, HCT116 colon cancer, and COC1 ovarian cancer cells, as well as human umbilical vein endothelial cells (HUVECs; IC50s = 4, 0.5, 3, 5, 5, and 8 nM, respectively). Chromomycin A2 (30 nM) halts the cell cycle in the G0/G1 phase and increases the protein levels of LC3A and LC3B in MALME-3M melanoma cells, indicating that it induces autophagy. It also increases the levels and promoter activity of the autophagic proteins ATG7 and ATG10 and reduces cell viability to 50% in human SCC-11 squamous cell carcinoma cells when used at a concentration of 30 nM.
    • 待估
    35日内发货
    规格
    数量
  • Neoanhydropodophyllol
    T4070862287-47-2
    Neoanhydropodophyllol, a cyclolignan derivative, exhibits potent antineoplastic activity by exerting cytotoxic effects on various cancer cell lines including leukemia, lung carcinoma, and colon carcinoma.
    • ¥ 9280
    待询
    规格
    数量
  • Dictamine
    白鲜碱, Dictamnine, Dectamine
    T5746484-29-7
    Dictamine (Dectamine) 显示抗胆碱酯酶、抗炎、致突变、抗菌和抗真菌活性。 它具有在人子宫颈、结肠和口腔癌细胞中发挥细胞毒性的能力。
    • ¥ 157
    In stock
    规格
    数量
  • b-raf in 8
    T607271215313-19-1
    B-Raf IN 8 (compound 7g) 是 B-Raf 的有效抑制剂 (IC50 = 70.65 nM)。B-Raf IN 8 显示出抗肿瘤活性,其对肝细胞癌 (HEPG-2)、结肠癌 (HCT-116),乳腺癌 (MCF-7) 和人前列腺癌 (PC-3) 细胞的 IC50值分别为9.78、13.78、18.52 和 29.85 μM。
    • ¥ 10600
    6-8周
    规格
    数量
  • b-raf in 7
    T609332477725-07-6
    B-Raf IN 7 (compound 6a) 是 B-Raf 的有效抑制剂,IC50值为 110.23 nM。B-Raf IN 7 对结肠癌细胞(HCT-116)、乳腺癌细胞 (MCF-7)、肝癌细胞 (HEPG-2)、人宫颈癌细胞 (Hela) 和人前列腺癌细胞 (PC-3) 具有抗肿瘤活性。其 IC50值分别为 7.50、9.87、10.57、11.63 和 12.83 μM。
    • ¥ 10600
    6-8周
    规格
    数量