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Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine 可用于改变真核生物寿命。

AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker, commonly employed in the synthesis of antibody-siRNA conjugates.

Amino-PEG4-(CH2)3CO2H is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-Aminooxy-PEG4-CH2CO2H is a polyethylene glycol (PEG) derivative serving as a PROTAC linker for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

(S,R,S)-AHPC-CO-C4-bromine 是合成PROTAC时使用的E3连接酶配体-连接子偶联物。此化合物包含E3连接酶配体和连接子两个成分。

Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH 是一种由 E3 连接酶配体和连接子组成的化合物，适用于合成 PROTAC 降解剂 MS4322。

Propargyl-PEG4-CH2CO2-NHS is a PEG derivative containing a propargyl group and an NHS group. The hydrophilic PEG spacer increases solubility in aqueous media.

Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan 为一种用于ADC中的drug-linker偶联物，其ADC毒素分子为Exatecan。

Ala-CO-amide-C4-Boc 为一种可降解 (cleavable) 的ADC linker，适用于抗体偶联活性分子 (ADC) 的合成。

PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) 是一款专为 PAC 设计的PROTAC-linker偶联物,采用了含有BRD4降解剂GNE-987的构造,并通过3个PEG的linker进行连接.该化合物也是一种效率高的点击化学试剂,内含Azide基团,可通过铜催化的叠氮-炔环加成反应(CuAAc)与含Alkyne基团的分子反应.此外,它还能通过与含DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应(SPAAC)进行反应.

PCO 400 是一种 comakalim 类似物，可作为一种选择性强的 ATP 敏感型 K+ 通道开放剂。

PROTAC-O4I2 是一种靶向剪接因子 3B1 (SF3B1) 的 PROTAC连接体， 在 K562 细胞中促使 FLAG-SF3B1 降解，IC50 值为 0.244 μM。PROTAC-O4I2 促使 K562 WT 细胞凋亡 (apoptosis)。

AtPCO4-IN-1是一种高选择性的AtPCO4抑制剂，具有IC50值为264.4μM。

4-Methylmorpholine N-oxide 常用作氧化反应中的共氧化剂和牺牲催化剂。

K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。

Gemcitabine elaidate (CP-4126) hydrochloride 是 Gemcitabine 的亲脂性前药。Gemcitabine elaidate hydrochloride 通过酯酶转化为 Gemcitabine 以被磷酸化。Gemcitabine elaidate hydrochloride 可以口服给药，具有抗肿瘤活性。

(S,R,S)-AHPC-O-CF3-CO-cyclohexane 属于 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 类型，该化合物在合成 PROTAC SMARCA2 4-degrader-20 中有重要应用。

(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin 属于 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 类型。此化合物主要应用于制备 PROTAC SMARCA2 4-degrader-23。

(S,R,S)-AHPC-CO-C-cyclohexane 作为一种 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates)，它用于制备 PROTAC SMARCA2 4-degrader-14。

Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) 是一种含有 NR2B 的 NMDA 受体拮抗剂。

Jamaicin (AnCoA4) 是一种从鸡血藤植物中提取的异黄酮，是一种 STIM1-Orai1 通道的抑制剂，可阻断钙离子流入，减少其与 STIM1 的相互作用，抑制 T 细胞的活化。

LISA-4 is the first fluorescent dipeptide probe for γ-glutamyl cyclotransferase.

α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng ml. α-GalCer analog 8 (32 ng ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.

BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the efflux pump P-glycoprotein (P-gp) but co-application of BAAA with a P-gp inhibitor, such as verapamil , inhibits BAA efflux.2BAAA-DA has been used to isolate human hematopoietic progenitor cells, which have high ALDH activity, andviaflow cytometry to sort cancer stem cells that contain high levels of ALDH.1,3BAA used in cells can be excited at 488 nm and displays an emission maximum of 512 nm.4 1.Storms, R.W., Trujillo, A.P., Springer, J.B., et al.Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activityProceedings of the National Academy of Sciences of the United States of America96(16)9118-9123(1999) 2.Smith, C.A., Colvin, M., Storms, R.W., et al.BODIPY aminoacetaldehyde diethyl acetal08010501.81-15(2010) 3.Leng, Z., Yang, Z., Li, L., et al.A reliable method for the sorting and identification of ALDHhigh cancer stem cells by flow cytometryExp. Ther. Med.(2017) 4.Pomper, M.G., Wang, H., Minn, I., et al.Red fluorescent aldehyde dehydrogenase (ALDH) substrate(2015)