Hyodeoxycholicacidsodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 synthesis.
Taurohyocholicacid (THCA), a taurine-conjugated form of porcine-specific primary bile acid hyocholicacid, inhibits cholesterol crystal precipitation by stabilizing cholesterol in the liquid-crystalline phase and prevents cholestasis and cellular necrosis in isolated rat livers induced by taurolithocholicacid. Additionally, THCA levels rise in the urine of patients with hepatitis B-induced cirrhosis.
Tauro-α-muricholicacid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholicacid . TαMCA is common in rodents but has also been found in small amounts in human serum.