c-16

PAF (C16) 是有效的 MAPK 和 MEK ERK 激活剂，可诱导血管通透性增加。PAF (C16) (PAF (C16)) 是血小板活化因子，是一种磷脂衍生介质，也是 PAF G 蛋白偶联受体 (PAFR) 的配体。PAF (C16) 在体外实验中显示出抗凋亡和抗炎活性，通过与其受体 （PAF-R） 相互作用以执行细胞信号传导来抑制 caspase 依赖性凋亡。

PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis

2-O-Ethyl PAF C-16 作为 PAF 的一种同系物，充当 PAF 受体（Platelet-activating Factor Receptor (PAFR)）的竞争型配体。它能够阻断 PAF 拮抗剂 WEB 2086 与 PAF 受体的结合，表现出 21 nM 的 IC50 值。

Lyso-PAF C-16 is a biologically inactive precursor of platelet activating factor.

Methylcarbamyl PAF C-16(Carbamyl-PAF) 是一种血小板活化因子类似物，具有 PAF 激动特性，可激活激活妊娠组织的炎症，促进早产。

2-O-methyl PAF C-16 is a synthetic analog of platelet-activating factor (PAF) featuring a methyl group attached via an ether linkage at the sn-2 position. While the specific biological activities of 2-O-methyl PAF C-16 remain undercharacterized, studies with its C-18 counterpart have demonstrated its ability to modulate various biological processes. These processes include reducing plasma membrane fluidity and hindering the invasiveness of tumor cells in embryonic chick hearts. Furthermore, in rat astrocytes, the C-18 analog prompts the release of significant amounts of nitric oxide (NO) through a mechanism that involves the activation of nitric oxide synthase (NOS).

C16 Ceramide (Palmitoyl Ceramide) 是一种天然小分子，通过直接选择性结合激活 p53。

Boc-C16-COOH 可以作为 ADC linker 或 PROTAC linker，用于合成抗体偶联药物或合成 PROTAC。

D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1 16:0)) 是内源性Mincle配体，具免疫刺激活性。

C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patients with ovarian carcinoma compared to those with benign ovarian tumors or uterine fibroids.

C16 3'-sulfo Galactosylceramide (d18:1 16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1 16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物，在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1 16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1 16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。

13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in ordered lipid domains (lipid rafts). Sphingomyelinases remove phosphorylcholine from C16 sphingomyelin to produce C16 ceramide. While ceramides commonly induce apoptosis, ceramides with different fatty acid chain lengths might direct distinct functions and, in some cases, reduce apoptosis.

C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid .

GLP-1R modulator C16 是一种变构调节剂，显著增加了 GLP-4 的结合亲和力。

C16 dihydro Ceramide (d18:0 16:0) (Cer(d18:0 16:0)) 是合成神经酰胺的前体，诱导核周区域自噬，可用于研究细胞膜的稳定性和神经系统疾病。

C16 Sphingomyelin (d18:1 16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物，可用于研究生物膜的活性。

PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化，解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。

C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro.

Boc-C16-NHS ester, an alkyl ether-based PROTAC linker, enables the synthesis of PROTACs[1].

Amino-PEG6-amido-C16-COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

C16 1-Deoxyceramide (m18:1 16:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 1246298-56-5。

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0 16:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 190249-36-6。

C16 PEG-Ceramide为一种聚乙二醇化神经酰胺，具备脂质载体传递功能，并能诱导自噬(autophagy)，在癌症研究中有应用。

C16 Ceramide-1-phosphate (d18:1 16:0) ammonium salt (C16 C1P ammonium salt) 是一种酯类产品，可用于合成纳米生物制。