c 5

Complement C5-IN-1 (Compound 7) 是补体成分蛋白5 (C5) 的小分子抑制剂。 Complement C5-IN-1 与 C5 相互作用以防止其被 C5 转化酶切割, 阻断酵母多糖诱导的 50％人全血 MAC 沉积的 IC50 值为 0.77 μM。

Biotin-C5-amino-C5-amino 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 分子的合成。

MC(C5)-Val-Cit is a cleavable ADC linker employed in ADCs synthesis [1].

Thalidomide-O-amide-C5-NH2 is a chemically synthesized conjugate, serving as an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide with a linker that is commonly employed in PROTAC technology.

Pomalidomide-C5-COOH 是一种合成的 E3 连接酶配体-接头偶联物，它结合了 PROTAC 技术中使用的基于 Pomalidomide 的 CRBN 配体和接头。

Boc-C5-O-C5-O-C6-Cl (PROTAC Linker 2) is a chemical compound commonly employed as a linker in PROTAC applications. Its primary function is to connect a specific tyrosine kinase inhibitor (TKI) with the E3 recruiting ligand.

(S,R,S)-AHPC-C5-NH2, also known as VH032-C5-NH2, is a synthetic compound designed as an E3 ligase ligand-linker conjugate. This compound combines the VH032-based von Hippel-Lindau (VHL) ligand with a linker, enabling it to function as a PROTAC degrader for estrogen-related receptor α (ERRα).

Thalidomide-O-C5-NH2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with E3 ligase activity. It combines a cereblon ligand based on Thalidomide and a linker commonly utilized in PROTAC technology.

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].

Thalidomide-O-C5-acid is a chemically synthesized conjugate that acts as an E3 ligase ligand-linker and combines the cereblon ligand derived from Thalidomide with a linker commonly utilized in PROTAC technology.

Modified MMAF-C5-COOH is a drug-linker conjugate for ADC.

C5 是一种高效且选择性的MAO-B抑制剂。

(S,R,S)-AHPC-Me-C5-COOH is a synthetic E3 ligase ligand-linker conjugate consisting of a VHL ligand and a linker. It finds application in PROTAC DT2216[1].

(S,R,S)-AHPC-amido-C5-acid is a chemical compound that contains a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It can be utilized in the design of XY028-133[1].

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].

Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) serves as a Lenalidomide-based Cereblon ligand that facilitates the recruitment of the CRBN protein. This compound can be connected to the protein's ligand through a linker, resulting in the formation of PROTAC[1].

Lenalidomide-C5-amido-Boc is a Cereblon ligand derived from Lenalidomide, and serves in the recruitment of CRBN protein. It can be effectively linked to the protein ligand through a linker, resulting in the formation of PROTAC.

Benzyloxy-C5-PEG1 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Compound PA, also known as Pomalidomide-CO-C5-azide, serves as a ligand for E3 ligase and features a bioorthogonal azide group. This compound is utilized in the synthesis of PROTACs that exhibit anticancer properties [1].

Thalidomide-O-C5-piperidine-NH-Boc 为一款 E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates)。该化合物主要应用于合成 PROTACPIN1degrader-1。

N3-C5-NHS ester 是一种不可切割的 ADC 接头，用于合成抗体-药物偶联物。

Pomalidomide-5-C5-NH2 hydrochloride is a Pomalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein and can be linked to a protein ligand via a linker to form PROTAC [1].

Compound 6b（Pomalidomide-CO-C5-Br）为E3连接酶配体Pomalidomide与连接子结合的偶联产物，适用于制备针对ACC的高效PROTAC分子。

Mal-C5-Gly-Gly-Phe-MMAE（Compound S5）是一种用于ADC的drug-linker conjugate。该化合物由MMAE和一种linker构成，主要应用于ADC的合成及癌症研究领域。