c 3

CB5660386 inhibitor of HIV-1 entry.

C3 functions as a selective inhibitor of monoamine oxidase B (MAO-B; IC50= 0.021 µM), demonstrating preference over monoamine oxidase A (MAO-A; IC50= 26.8 µM). This compound, at dosages of 0.1, 1, and 3 mg kg, effectively counters MPTP-induced reductions in dopamine levels within the mouse brain.

Azenosertib (ZN-c3) 是一种有效的选择性 Wee1 抑制剂，具有平衡的效力、ADME 和药代动力学特性。[1]

SMN-C3 (MV8T2MCK57) 是口服有效的 SMN2 剪接调节剂。SMN-C3可用于脊椎肌肉萎缩 (SMA) 的研究。

Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。

Thalidomide-O-C3-acid is a chemically derived conjugate that combines a cereblon ligand based on Thalidomide and a linker commonly employed in PROTAC technology. This synthesized E3 ligase ligand-linker conjugate serves to facilitate targeted protein degradation.

APN-C3-PEG4-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Pomalidomide-C3-NH2 hydrochloride 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，是合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成。

Br-C3-methyl ester is an alkyl ether-based PROTAC linker utilized for the synthesis of PROTAC PD-1 PD-L1 degrader-1.

Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised of the non-alkylating group. It is a sequence-selective DNA minor-groove binding agent.

Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 , a drug-linker conjugate for ADC.

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized conjugate compound that serves as an E3 ligase ligand-linker. It features a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology.

Chloroacetamido-C-PEG3-C3-NHBoc is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs).

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker employed in PROTAC synthesis[1].

Tetrazine-Ph-NHCO-C3-NHS ester是一种源于PEG的PROTACs合成连接剂。

Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1 2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in vivo pharmacokinetic properties.

(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized conjugate consisting of an E3 ligase ligand-linker and the VH032 based VHL ligand, which is commonly used in PROTAC technology. This compound serves as a key component in the synthesis of various PROTACs, including UNC6852. UNC6852 is a bivalent chemical degrader specifically targeting EED [1].

Pomalidomide-amido-C3-COOH is a conjugate compound synthesized as an E3 ligase ligand-linker. It combines a cereblon ligand derived from Pomalidomide with a linker, both of which are used in PROTAC technology.

APN-C3-NH-Boc is a alkyl ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

APN-C3-PEG4-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-SS-C3-sulfo-NHS ester is a cleavable ADC linker employed for the synthesis of antibody-drug conjugates (ADCs).

Pomalidomide-C3-I 是一种合成的 E3 连接酶配体-接头偶联物，它结合了 PROTAC 技术中使用的基于 Pomalidomide 的 CRBN 配体和接头。

(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, suc