antibodies

B7 CD28 interaction inhibitor 1 (CTLA-4 inhibitor) 是B7.1-CD28相互作用抑制剂(IC50:50 nM)。

Macropa-NH2 是 macropa 双功能类似物，是一种常与抗体偶联的载体分子，常作为螯合剂使用，参与癌症研究。

VA-K-14 hydrochloride（VAK14 HCl）是一种选择性促甲状腺激素受体 (TSHR) 拮抗剂 (IC50= 12.3 μM)，对GD患者血清和单克隆刺激TSHR抗体对TSHR的刺激有抑制作用，可消除 TSHR 信号传导。

Avacopan (CCX168) 是一种 C5aR 拮抗剂 (IC50=0.1 nM)，具有选择性和口服活性。Avacopan 可阻断 C5a 的作用并防止 AAV 小鼠模型中抗髓过氧化物酶抗体诱导的 GN 发展。Avacopan 可以用于治疗抗中性粒细胞胞浆抗体 (ANCA) 相关血管炎。

ABBV-969 Payload(Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT)是用于合成ADC 的药物-连接物偶联物，含有Topo I（拓扑异构酶1）抑制分子和连接分子，可以与抗c-Met抗体偶联形成ABBV-969。

Fmoc-Ala-Ala-Asn(Trt)-OH 是一种可切割的 ADC 接头，用于抗体-药物偶联物。

fmoc-L-2-cyanophenylalanine 是氨基酸苯丙氨酸的衍生物，由于其优异的反应性和稳定性，被广泛用于肽合成，以及合成各种其他生物活性分子，如肽激素、酶和抗体。

Rhodopsin Epitope Tag acetate 是一种 9 个氨基酸的肽，代表牛视紫红质的 C 末端，广泛用作表位标签。许多抗视紫红质抗体可以识别该表位。

DM3-SMe is a maytansine derivative and tubulin inhibitor. It is a cytotoxic part of antibody-drug conjugates (ADCs) and can bind to antibodies via disulfide bonds or stable thioether bonds. DM3-SMe has high cytotoxic activity in vitro with IC50 of 0.0011

Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Ald-Ph-amido-PEG2-C2-NHS ester is a non-cleavable 2-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Aminoethyl-SS-propionic acid is an ADC linker compound employed in ADC synthesis [1]. It functions as a cleavable linker in the conjugation of antibodies with drugs, allowing for targeted drug delivery.

Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl ether moieties.

BDP FL DBCO is a cleavable linker vital in ADC synthesis. BDP FL DBCO joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Biotin Hydrazide 是一种羰基反应性生物素化试剂，是羰基探针。

Bis-PEG1-NHS ester是一种不可降解和只含有1个单元 PEG 的 ADC linker，Bis-PEG1-NHS ester可用于合成抗体偶联活性分子 (ADC) 。

Boc-Cystamine is a cleavable linker vital in ADC synthesis. Boc-Cystamine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

Fmoc-NH-ethyl-SS-propionic NHS ester is a cleavable linker for antibody-drug conjugates (ADCs)[1]. It is employed in the synthesis of ADCs, facilitating the covalent attachment of drugs to antibodies through the formation of stable amide bonds.

JNJ4796 is an oral active fusion inhibitor of the influenza virus, by inhibiting hemagglutinin (HA)-mediated fusion to neutralizing the influenza A group 1 virus. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs).

m-PEG8-Amine is a cleavable linker vital in ADC synthesis. m-PEG8-Amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker employed in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2]. It acts as a cleavable ADC linker, facilitating the conjugation of drugs to antibodies for targeted delivery [2].

Propargyl-PEG1-NHS ester is a non-cleavable 1-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Propargyl-PEG4-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Tr-PEG4-OH is a non-cleavable tetraethylene glycol ADC linker employed in ADC synthesis for the conjugation of antibodies and drugs.