aminopeptidase a

Firibastat (RB150) 是一种具有口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A(APA) 抑制剂 (Ki=200 nM)，选择性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III，降低血压。

Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N CD13 (IC50 = 25 μM). It is selective for AP-N CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.

AminopeptidaseN Ligand (CD13) NGR peptide 是靶向CD13的多肽，常见于癌症研究中，用作细胞内传递的载体介质。

Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N) APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。

L(+)-Leucinol 是一种有效的亮氨酸氨基肽酶抑制剂。

TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.

ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。

ERAP1-in-1 是一种内质网氨基肽酶 1 (ERAP1) 抑制剂，能竞争性地抑制 ERAP1 对代表性生物底物九聚物肽的作用。

TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).

Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

SB-587094 是一种可逆的蛋氨酸氨肽酶-2（MetAP-2）抑制剂。

ERAP1 modulator-1 (Compound 1) 是一种调节内质网氨肽酶 1 (ERAP1) 的化合物，具有 IC50 值小于 250 nM。

ERAP1-IN-3 (compound 13) 是一种强效的内质网氨基肽酶 1 ERAP1 抑制剂，其 pIC50 值为 8.6。ERAP1-IN-3 有望用于癌症免疫和自身免疫性疾病的研究。

L-Leucine-p-nitroanilide is a substrate. It is used for the colorimetric determination of leucine aminopeptidase.

Apstatin TFA 是一种强效氨基肽酶 P (aminopeptidase P, APP) 抑制剂，对大鼠和人类 APP 的Ki值分别为 2.6 µM 和 0.64 µM。此外，Apstatin TFA 还具有心脏保护作用。

ARM1 是氨基肽酶和环氧化物水解酶抑制剂，IC50分别为为7.61 µM 和12.4 µM。

Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 µM .

Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.

Ketomethylenebestatin is a carba-analog of bestatin，the aminopeptidase (AP) inhibitor. Ketomethylenebestatin is 10 fold less effective as an inhibitor of aminopeptidases than bestatin.

Microginin 527, a compound found in Microcystis, is an inhibitor of protein phosphatase, ACE, and leucine aminopeptidase.

7-Lysylalanyl-4-methylcoumarinamide is a Fluorogenic substrate for dipeptidyl aminopeptidase.

Leucylmethionine is a substrate for aminopeptidase M.

Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 μM.