acyl

MPI_5a 是高效的 HDAC6选择性抑制剂，IC50=36 nM，对其他 HDAC 酶几乎无抑制作用。MPI_5a 抑制细胞内酰基微管蛋白积累， IC50为 210 nM。

Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), the acyl glucuronide formation of thyroxine (T4), an endogenous metabolite.

T3 Acyl glucuronide is the acyl glucuronide formation of triiodothyronine (T3). T3 Acyl glucuronide is an endogenous metabolite

Diclofenac Acyl Glucuronide (Diclofenac glucuronide) 是一种肠道代谢物，可加速肠道溃疡。

Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat . Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (UGTs).

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan . It does not bind human serum albumin and is cleared from rat plasma with a clearance rate of 180 ml min kg following intravenous administration.

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

Etodolac acyl glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac .1It is formedviaglucuronidation of etodolac by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A10, and UGT2B7. 1.Kutsuno, Y., Itoh, T., Tukey, R.H., et al.Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 miceDrug Metab. Dispos.42(7)1146-1152(2014)

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.

Methyl-PEG4-acyl chloride is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ferulic acid acyl-β-D-glucoside, a metabolite of Ferulic Acid, is a novel inhibitor of fibroblast growth factor receptor 1 (FGFR1). It exhibits IC50 values of 3.78 µM and 12.5 µM for FGFR1 and FGFR2, respectively.

UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) 是一种E. coli 代谢产物，参与 3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。

Acyl coenzyme A synthetase (ACS)，一种生化研究中常用的酶，主要通过两步硫酯化反应激活脂肪酸与辅酶A结合，形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径，以及参与TCA循环中的有氧呼吸提供了关键中间物。

UDP-3-O-acyl-GlcNAc diammonium 是一种E. coli代谢产物，涉及3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。

Dabigatran acyl-β-D-glucuronide是凝血酶抑制剂dabigatran的一种活性代谢产物，主要通过UDP-葡萄糖醛酸转移酶(UGT)的UGT2B15亚型形成。在人体去除血小板的贫血浆中，Dabigatran acyl-β-D-glucuronide (0.46 µM) 能增加活化部分凝血活酶时间(aPTT)。

Indomethacin acyl glucuronide, a metabolite of the COX inhibitor indomethacin (1), embodies an essential byproduct formed during the metabolic processing of indomethacin.

Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.

(S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) 作为 S-布洛芬的一种酰基葡萄糖醛酸代谢产物，主要存在于肝脏中。该化合物广泛应用于研究 S-布洛芬的代谢过程及药代动力学，S-布洛芬为常用的非甾体抗炎药。

UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) Tris 是由E. coli 产生的一种代谢物，其功能包括参与3-deoxy-D-manno-octulosonate (KDO) 的生物合成途径。

Acyl Carrier Protein (ACP) (65-74) is an active fragment of ACP, a component of plastid-located plant fatty acid synthetase. It covalently binds acyl groups via the prosthetic group, 4-phosphopantetheine.

2,3,4,6-Tetra-O-acetyl-PtdGlc(di-acyl Chain)是一种高纯度生化试剂，适合作为生物材料或有机合成中间体，广泛应用于生命科学领域的研究与实验。

6-OAc PtdGlc(di-acyl Chain)是一种高纯度生化试剂，适合作为生物材料或有机合成中间体，广泛应用于生命科学领域的研究与实验。

(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) 为一种具抗炎活性的化合物代谢物。此化合物能作为前谷氨酰肽酶1的敏感荧光底物使用，裂解时产生蓝色荧光。