acyl

MPI_5a属于小分子抑制剂，是一种高选择性HDAC6抑制剂（IC50=36 nM），MPI_5a 抑制细胞内酰基微管蛋白的积累的 IC50 值为 210 nM，用于HDAC6功能研究。

Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), the acyl glucuronide formation of thyroxine (T4), an endogenous metabolite.

T3 Acyl glucuronide is the acyl glucuronide formation of triiodothyronine (T3). T3 Acyl glucuronide is an endogenous metabolite

Azido-PEG4-acyl chloride 是一种 PEG 类的PROTAC linker，适用于合成PROTAC分子。作为点击化学试剂，Azido-PEG4-acyl chloride 含有 Azide 基团，可与含 Alkyne 基团的分子通过铜催化的叠氮-炔环加成反应（CuAAc）发生作用。它也可与含 DBCO 或 BCN 基团的分子进行环张力驱动的炔-叠氮环加成反应（SPAAC）。

Benzyl-PEG4-acyl chloride 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

Mycophenolic acid acyl-β-D-glucuronide (Acyl-MPAG) 是 mycophenolic acid (一种免疫抑制剂) 的一种代谢产物。

Diclofenac Acyl Glucuronide (Diclofenac glucuronide) 是一种肠道代谢物，可加速肠道溃疡。

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan . It does not bind human serum albumin and is cleared from rat plasma with a clearance rate of 180 ml/min/kg following intravenous administration.

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

Etodolac acyl glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac .1It is formedviaglucuronidation of etodolac by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A10, and UGT2B7. 1.Kutsuno, Y., Itoh, T., Tukey, R.H., et al.Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 miceDrug Metab. Dispos.42(7)1146-1152(2014)

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.

Methyl-PEG4-acyl chloride is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ferulic acid acyl-β-D-glucoside, a metabolite of Ferulic Acid, is a novel inhibitor of fibroblast growth factor receptor 1 (FGFR1). It exhibits IC50 values of 3.78 µM and 12.5 µM for FGFR1 and FGFR2, respectively.

UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) 是一种E. coli 代谢产物，参与 3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。

Acyl coenzyme A synthetase (ACS)，一种生化研究中常用的酶，主要通过两步硫酯化反应激活脂肪酸与辅酶A结合，形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径，以及参与TCA循环中的有氧呼吸提供了关键中间物。

UDP-3-O-acyl-GlcNAc diammonium 是一种E. coli代谢产物，涉及3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。

Dabigatran acyl-β-D-glucuronide是凝血酶抑制剂dabigatran的一种活性代谢产物，主要通过UDP-葡萄糖醛酸转移酶(UGT)的UGT2B15亚型形成。在人体去除血小板的贫血浆中，Dabigatran acyl-β-D-glucuronide (0.46 µM) 能增加活化部分凝血活酶时间(aPTT)。

Indomethacin acyl glucuronide, a metabolite of the COX inhibitor indomethacin (1), embodies an essential byproduct formed during the metabolic processing of indomethacin.

Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.

(S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) 作为 S-布洛芬的一种酰基葡萄糖醛酸代谢产物，主要存在于肝脏中。该化合物广泛应用于研究 S-布洛芬的代谢过程及药代动力学，S-布洛芬为常用的非甾体抗炎药。

Dabigatran acyl-β-D-glucuronide-13C6 是一种使用 13C 标记的 Dabigatran acyl-β-D-glucuronide。

UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) Tris 是由E. coli 产生的一种代谢物，其功能包括参与3-deoxy-D-manno-octulosonate (KDO) 的生物合成途径。

Acyl Carrier Protein (ACP) (65-74) is an active fragment of ACP, a component of plastid-located plant fatty acid synthetase. It covalently binds acyl groups via the prosthetic group, 4-phosphopantetheine.