Rbin-1

Rbin-1 (Ribozinoindole-1) 是一种选择性 Midasin 抑制剂，是一种可逆的、特异性真核核糖体生物合成抑制剂，GI50=136 nM。

MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of bacterial cell wall. With a binding affinity of K d 3.57 μM, MurB-IN-1 effectively hinders the activity of MurB, presenting a promising therapeutic option against P. aeruginosa, a highly virulent and opportunistic pathogen associated with severe infections and mortality [1].

AcrB-IN-1 (Compound H6) 是一种有效的 AcrB 抑制剂。AcrB-IN-1 可用于逆转细菌多药耐药。

Factor B-IN-1 is a Factor B inhibitor.