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Search Results for " nsc 139486 "
Targets Recommended: TRP/TRPV Channel

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Cat. No. Product Name Target Signaling Pathways
T8607 M084

正丁基-1H-苯并[D]咪唑基-2-胺,M-084 hydrochloride,1H-Benzimidazol-2-amine,N-butyl-(9CI),N-Butyl-1H-benzimidazol-2-amine

TRP/TRPV Channel Membrane transporter/Ion channel
M084 (N-Butyl-1H-benzimidazol-2-amine) 是 TRPC4/5 通道的阻断剂,具有抗抑郁和抗焦虑作用。
T37823 M 084 hydrochloride

Others Others
TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo. Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID:25816897 |Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136...

化合物

M084
Cat.No: T8607
Synonym: 正丁基-1H-苯并[D]咪唑基-2-胺,M-084 hydrochloride,1H-Benzimidazol-2-amine,N-butyl-(9CI),N-Butyl-1H-benzimidazol-2-amine
Target: TRP/TRPV Channel
M 084 hydrochloride
Cat.No: T37823
Synonym:
Target: Others
TargetMol Loading
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