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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T33216	Mazaticol hydrochloride PG-501,Mazaticol HCl,KAO 264
	Mazaticol hydrochloride is a bioactive chemical.
T20600	Kaolin Clay 347,Hydrated aluminum silicate,Bolus alba,HSDB 630,Altowhite,China clay,高岭土	Others	Others
	Kaolin (Bolus alba) 是一种以高岭石族矿物为主的粘土。 Kaolin 提高了这种监测血友病治疗方法的敏感性。
T131567	Epicatechin (Epicatechol; Acacatechin; Kakaol)
	Epicatechin (Epicatechol; Acacatechin; Kakaol) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131567。

化合物

Mazaticol hydrochloride

Cat.No: T33216

Synonym: PG-501,Mazaticol HCl,KAO 264

Target:

Kaolin

Cat.No: T20600

Synonym: Clay 347,Hydrated aluminum silicate,Bolus alba,HSDB 630,Altowhite,China clay,高岭土

Target: Others

Epicatechin (Epicatechol; Acacatechin; Kakaol)

Cat.No: T131567

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN5013	Shizukaol D	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be used to treat metabolic syndrome, it induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation.
TN5011	Shizukaol B	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul
TN5351	Cycloshizukaol A
	Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 0.9 microM.
TN5010	Shizukaol A	Others	Others
	Shizukaol A is a natural product from Chloranthus japonicus.
T81166	Shizukaol G
	Shizukaol G为一种从Chloranthus japonicus根部分离得到的二聚倍半萜烯。
TN5012	Shizukaol C	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>

天然产物

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Target: HIV Protease, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00140	ABP1/AOC1 Protein, Human, Recombinant (His) amine oxidase, copper containing 1,DAO,ABP1,ABP,KAO...	Human	HEK293 Cells
	Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under co...
TMPH-03037	Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) Alpha-CT,Alpha-Ctx,Alpha-EPTX-Nk2a,Long neurotoxin 1,Alpha-C...	Naja kaouthia	E. coli
	Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2)...
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 homolog,CVFk,CVF	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...