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Search Results for " ifnar "

Targets Recommended: IFNAR Others IFNAR

12

抑制剂 & 化合物

1

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11630	IFN alpha-IFNAR-IN-1 hydrochloride	Others; IFNAR	Immunology/Inflammation; Others
	IFN alpha-IFNAR-IN-1 hydrochloride 是 IFN-α 和 IFNAR 相互作用的抑制剂。 IFN alpha-IFNAR-IN-1 hydrochloride 抑制 BM-pDCs 的 MVA 诱导的 IFN-α 反应，IC50 为 2-8 μM。
T11630L	IFN alpha-IFNAR-IN-1	Others	Others
	IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. It inhibits MVA-induced IFN-α responses by BM-pDCs (IC50: 2-8 μM).
T13736	Interferon receptor inducer-1	IFNAR	Immunology/Inflammation
	Interferon receptor inducer-1 是一种干扰素(IFN)受体诱导剂，可用于干扰素诱导参与的紊乱性疾病的研究。
T14687	Deucravacitinib BMS-986165	Tyrosine Kinases; JAK; IFNAR; Interleukin	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂，用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活，可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域，IC50为1.0 nM。
T12933	SM-276001	TLR; COX	Immunology/Inflammation; Neuroscience
	SM-276001 是可口服的干扰素诱导剂，是选择性TLR7激动剂，可以诱导抗肿瘤免疫反应。
T5317	Cridanimod CMA,吖啶酮乙酸,XBIO-101,10-carboxymethyl-9-acridanone	Progesterone Receptor; STING; IFNAR	Immunology/Inflammation; Others
	Cridanimod (10-carboxymethyl-9-acridanone, CMA) 是一种是小分子免疫调节剂和干扰素诱导剂，是一种孕酮受体激活剂，能够诱导 IFNα和IFNβ的表达，显著增加 PR 的表达。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T7081	CCCP Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙	Apoptosis; IκB/IKK; COX; Mitochondrial Metabolism; STING; IFNAR; Antibacterial	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂，线粒体质子载体解偶联剂。CCCP 抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。
T6273	Vadimezan DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404	Influenza Virus; VDA; STING; IFNAR	Angiogenesis; Immunology/Inflammation; Microbiology/Virology
	Vadimezan (DMXAA) 是一种血管破坏剂，一种鼠 STING 激动剂，也是一种细胞因子如 I 型 IFN 的诱导剂。Vadimezan 具有抗肿瘤活性，可以诱导肿瘤中的血流快速停止，但不影响正常组织中的血流。
T22142	RO8191 RO4948191,CDM-3008	HCV Protease; HBV; JAK; IFNAR; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	RO8191 (CDM-3008) 是干扰素 (IFN) 受体激动剂。它直接与 IFNα/β 受体 2 结合，激活 IFN 刺激的基因表达和 JAK/STAT 磷酸化。它通过具有干扰素样活性发挥 cccDNA 调节剂作用，并具有抗 HBV 活性。
T78263	Anti-Mouse IFNAR1 Antibody (MAR1-5A3)	IFNAR	Immunology/Inflammation
	Anti-MouseIFNAR1Antibody (MAR1-5A3) 为IFNAR1中和抗体，可在体内外与IFNAR1结合并阻断信号传导。MouseIgG1kappa, Isotype Control 作为 Anti-MouseIFNAR1Antibody (MAR1-5A3) 的同型对照使用。
T38161	STING Agonist C11 STING Agonist C11
	STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro...

化合物

IFN alpha-IFNAR-IN-1 hydrochloride

Cat.No: T11630

Target: Others, IFNAR

IFN alpha-IFNAR-IN-1

Cat.No: T11630L

Target: Others

Interferon receptor inducer-1

Cat.No: T13736

Target: IFNAR

Deucravacitinib

Cat.No: T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Cat.No: T12933

Target: TLR, COX

Cat.No: T5317

Synonym: CMA,吖啶酮乙酸,XBIO-101,10-carboxymethyl-9-acridanone

Target: Progesterone Receptor, STING, IFNAR

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Cat.No: T7081

Synonym: Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙

Target: Apoptosis, IκB/IKK, COX, Mitochondrial Metabolism, STING, IFNAR, Antibacterial

Cat.No: T6273

Synonym: DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404

Target: Influenza Virus, VDA, STING, IFNAR

Cat.No: T22142

Synonym: RO4948191,CDM-3008

Target: HCV Protease, HBV, JAK, IFNAR, STAT

Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

Cat.No: T78263

Target: IFNAR

STING Agonist C11

Cat.No: T38161

Synonym: STING Agonist C11

Cat. No.	Product Name	Target	Signaling Pathways
T3829	Ginsenoside F3 人参皂苷F3	Others; IFNAR; Interleukin	Immunology/Inflammation; Others
	Ginsenoside F3 是一种皂苷，提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达，有免疫增强的作用。

天然产物

Cat.No: T3829

Synonym: 人参皂苷F3

Target: Others, IFNAR, Interleukin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02647	IFNAR1 Protein, Human, Recombinant (His) interferon (alpha, beta and omega) receptor 1,IFN-α-REC,IFRC...	Human	HEK293 Cells
	IFNAR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.6 kDa and the accession number is P17181-1.
TMPK-00342	IFNAR1 Protein, Mouse, Recombinant (His & Avi) IFN-α-REC,IFN-R-1,IFNAR1,IFN-alpha/β R1,IFRC,IFN α/...	Mouse	HEK293 Cells
	IFNAR1 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 46.9 kDa and the accession number is P33896.
TMPY-01489	IFNAR1 Protein, Mouse, Recombinant (His) Ifrc,Ifar,CD118,interferon (α, β and ω) receptor 1,interfero...	Mouse	HEK293 Cells
	IFNAR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is P33896.
TMPK-00326	IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated IFN-alpha/β R1,IFN-α/β R1,IFN α/β R1,IFN-R-1,IFN-alpha-REC,I...	Human	HEK293 Cells
	IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.2 kDa and the accession number is P17181-1.
TMPK-00343	IFNAR1 Protein, Mouse, Recombinant (hFc) AVP,IFNBR,IFN-alpha/β R1,IFNAR,IFN-aR1,IFN-α-REC,IF...	Mouse	HEK293 Cells
	IFNAR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 72.5 kDa and the accession number is P33896.
TMPK-00325	IFNAR1 Protein, Human, Recombinant (His & Avi) AVP,IFN-alpha-REC,IFN-α/β R1,IFNAR,IFN α/β R1,IFN-a...	Human	HEK293 Cells
	IFNAR1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.2 kDa and the accession number is P17181-1.
TMPY-02634	IFNAR1 Protein, Human, Recombinant (hFc) interferon (α, β and Ω) receptor 1,IFNBR,AVP,IFN-α-REC,IFN-a...	Human	HEK293 Cells
	IFNAR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74 kDa and the accession number is P17181-1.
TMPY-04799	IFNAR2 Protein, Human, Recombinant (His), Biotinylated IFN-R,interferon (α, β and Ω) receptor 2,IFNABR,interferon (...	Human	HEK293 Cells
	IFNAR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P48551-1.
TMPK-00889	IFNAR2 Protein, Human, Recombinant (aa 27-243, His) IFN-alpha/beta R2,IFNAR2,IFNbR2,IFNABR,IFN α/β R2,<...	Human	HEK293 Cells
	Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well. IFNAR2 Protein, Human, Recombinant (aa 27-243, His) is expressed in HEK293 mammalian cells with C-His t...
TMPK-00637	IFNAR2 Protein, Cynomolgus, Recombinant (aa 27-243, His) β receptor10,IFNbR2,IFN α/β R2,IFN-R,IFNAR2,β recep...	Cynomolgus	HEK293 Cells
	Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well. IFNAR2 Protein, Cynomolgus, Recombinant (aa 27-243, His) is expressed in HEK293 mammalian cells with C-...
TMPY-01640	IFNAR2 Protein, Human, Recombinant (hFc) interferon (α, β and ω) receptor 2,IFNABR,IFN-R,interferon (...	Human	HEK293 Cells
	IFNAR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.8 kDa and the accession number is P48551-1.
TMPH-02732	IFNAR2 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.; May be potent inhibitors of type I IFN receptor activity.; May be potent inhibitors of type I IFN receptor activity. IFNAR2 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.8 ...
TMPY-03927	IFNAR1 Protein, Rhesus, Recombinant interferon (α, β and ω) receptor 1,interferon (alpha, beta a...	Rhesus	HEK293 Cells
	IFNAR1 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 48.3 kDa and the accession number is H9Z8H4.
TMPY-04254	IFNAR1 Protein, Rhesus, Recombinant (His) interferon (alpha, beta and omega) receptor 1,interferon (α,...	Rhesus	HEK293 Cells
	IFNAR1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.7 kDa and the accession number is H9Z8H4.
TMPY-03829	IFNAR1 Protein, Rhesus, Recombinant (hFc) interferon (α, β and Ω) receptor 1,interferon (alpha, beta a...	Rhesus	HEK293 Cells
	IFNAR1 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is H9Z8H4.
TMPY-01642	IFNAR2 Protein, Human, Recombinant (His) IFNARB,IFNABR,interferon (α, β and ω) receptor 2,IF...	Human	HEK293 Cells
	IFNAR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P48551-1.
TMPY-00139	IFNAR2 Protein, Cynomolgus, Recombinant (His) interferon (α, β and Ω) receptor 2,interferon (alpha, beta a...	Cynomolgus	HEK293 Cells
	IFNAR2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is XP_005548871.1.
TMPJ-00331	IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al,CRF2-1,IFN-alpha/beta receptor 1,human interferon-α r...	Rhesus	HEK293 Cells
	Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory...

重组蛋白

IFNAR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02647

Species: Human

Expression System: HEK293 Cells

IFNAR1 Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-00342

Species: Mouse

Expression System: HEK293 Cells

IFNAR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01489

Species: Mouse

Expression System: HEK293 Cells

IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00326

Species: Human

Expression System: HEK293 Cells

IFNAR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00343

Species: Mouse

Expression System: HEK293 Cells

IFNAR1 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00325

Species: Human

Expression System: HEK293 Cells

IFNAR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02634

Species: Human

Expression System: HEK293 Cells

IFNAR2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04799

Species: Human

Expression System: HEK293 Cells

IFNAR2 Protein, Human, Recombinant (aa 27-243, His)

Cat.No: TMPK-00889

Species: Human

Expression System: HEK293 Cells

IFNAR2 Protein, Cynomolgus, Recombinant (aa 27-243, His)

Cat.No: TMPK-00637

Species: Cynomolgus

Expression System: HEK293 Cells

IFNAR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01640

Species: Human

Expression System: HEK293 Cells

IFNAR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02732

Species: Mouse

Expression System: P. pastoris (Yeast)

IFNAR1 Protein, Rhesus, Recombinant

Cat.No: TMPY-03927

Species: Rhesus

Expression System: HEK293 Cells

IFNAR1 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-04254

Species: Rhesus

Expression System: HEK293 Cells

IFNAR1 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03829

Species: Rhesus

Expression System: HEK293 Cells

IFNAR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01642

Species: Human

Expression System: HEK293 Cells

IFNAR2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-00139

Species: Cynomolgus

Expression System: HEK293 Cells

IFNAR1 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00331

Species: Rhesus

Expression System: HEK293 Cells

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