γgt

γ-GT (H-GLA(PNA)-OH) 是一种 γ-谷氨酰转移酶(glutamyl transferase)的底物。

GT 949 是氨基酸转运蛋白 2 (EAAT2) 的选择性兴奋性正变构调节剂 (EC50：0.26 nM)。

GT-653 是针对赖氨酸特异性脱甲基酶 5B (KDM5B) 的 PROTAC 降解剂。它通过依赖泛素蛋白酶的机制，以 10 μM 浓度达成 68.35% 的 KDM5B 降解率。该化合物还能提高 H3K4me3 水平，并在前列腺癌细胞系 22RV1 中激活 I 型干扰素信号通路。

GT-02216可以异位结合GCase并增强其活性。在主要人类成纤维细胞中，GT-02216提高了GCase的活性。GT-02216减少了突变GBA1成纤维细胞中的Tau积累。GT-02216在大鼠模型中保护面临Tau低聚物挑战的海马初级神经元。

GT 2016 is a H3 receptor antagonist.

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor. [2] Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM [3] . Ganglioside GT1b mixture contains ganglioside GT1b molecular species with C18:1 and C20:1 sphingoid backbones.

GT-1 (LCB10-0200) is a siderophore-linked cephalosporin compound that effectively combats clinical isolates of various bacterial species, including P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.

GT-055 (LCB18-055) 是一种广谱 β-lactamase 的新型抑制剂。

GT-11 is an inhibitor of dihydroceramides (DHCer) desaturase activity.

GT951 is a EAAT2 activator.

GT-2331 is a histamine H3 receptor antagonist.

GT-2394 is a histamine H3 receptor agonist.

GT-2227 is a histamine H3 receptor antagonist.

GT-0198 is a novel glycine transporter 2 inhibitor showed activity in a mouse model of neuropathic pain. GT-0198 inhibited the function of glycine transporter 2 (GlyT2) in human GlyT2-expressing HEK293 cells and did not bind various major transporters or receptors of neurotransmitters in a competitive manner. GT-0198 is considered to be a comparatively selective GlyT2 inhibitor. GT-0198 is a structurally novel GlyT2 inhibitor bearing a phenoxymethylbenzamide moiety with in vivo efficacy in behavioral models of neuropathic pain.

Thifensulfuron-methyl (Pinnacle) 是磺酰脲类除草剂，可用于防治玉米，小麦和大豆田中的阔叶杂草。

Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorde

Proxalutamide 是具有口服活性的雄激素受体的拮抗剂。它可研究前列腺癌和COVID-19。

Deferitrin (GT-56-252) 是一种具有口服活性的三叉戟铁螯合剂，是去铁硫素 (DFT) 类似物。它有用于严重的 β 地中海贫血的潜力。它用于输血引起的慢性铁超负荷。

Ganglioside GT1b bovine trisodium 是一种三唾液酸神经节苷脂，它能够与 A 型肉毒杆菌毒素 (BTxA)、BTxA 重链和破伤风毒素结合，IC50值分别为 11、0.74 和 7.2 μM。在脊髓微胶质细胞中，Ganglioside GT1b bovine trisodium 作为TLR2激动剂，诱导微胶质激活，提升促炎因子表达并增加痛觉敏感性。此化合物还可以降低人外周血单核细胞 (PBMC) 中 IL-6、IL-10、IgG、IgM 和 IgA 的生成，并在神经细胞模型中提升细胞外谷氨酸水平。Ganglioside GT1b bovine trisodium 适用于研究免疫系统疾病、神经系统疾病等领域。

Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.

Indantadol HCl (CHF-3381) 是一种 NMDA 拮抗剂和非选择性 MAO 抑制剂。

NIBR-1282 is a CCR5 antagonist.

Evatanepag, also known as CP-533536, is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing.

CVS-1578 is a potent serine protease inhibitor, targeting the S2S3 thrombin and FXa subsites.