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12

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35417	α-Linolenic Acid (sodium salt)
	α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.
T41323	Dihomo-γ-Linolenic acid methyl ester	Others	Others
	Dihomo-γ-Linolenic acid methyl ester 是 Dihomo-γ-Linolenic acid 的甲酯形式，Dihomo-γ-Linolenic acid 具有抗炎和抗增殖作用。
T41235	γ-Linolenic acid ethyl ester
	γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) 是一种白三烯 B 受体 4(LTB4)的拮抗剂，具有潜在的抗炎作用。
T40880	(±)-Jasmonic acid
	(±)-Jasmonic acid, a plant growth regulator and derivative of α-linolenic acid, exhibits chlorophyll-lowering effects in green and etiolated barley leaf segments, while also inhibiting the elongation of rice seedlings.
T36170	A1-Phytoprostane-I A1-Phytoprostane-I
	A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants. There are two A1-phytoprostanes, both having the single ketone group on the ring structure. This isoform results from cyclization between carbons 9 and 13 of linolenic acid, as opposed to carbons 3 and 7 in A1-phytoprostane-II. A1-Phytoprostanes induce the expression of glutathione-S-transferase, increase phytoalexin biosynthesis, and trigger the expression of sever...
T36773	12(S)-HETrE
	12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.
T37865	9(S)-HOTrE
	9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid. 9(S)-HOTrE is predominantly localized in cellular ester lipids of Glechoma hederacea leaves and is partially released during artificial dehydration. The biological role of 9(S)-HOTrE in G. hederacea leaves is still undetermined, but it may play a role in natural senescence. 9(S)-HOTrE is an inhibitor of spore germination and germ tube elongation of rice blast fungus with ED50 valu...
T83761	12-oxo-9(Z)-Dodecenoic Acid 12-oxo-9-cis-Dodecenoic Acid,12-keto-9Z-Dodecenoic Acid
	12-oxo-9(Z)-Dodecenoic acid 是一种 ω-oxoacid 和 ω-6 PUFA 亚麻酸及ω-3 PUFA α-亚麻酸的代谢产物。通过植物中的脂氧合酶产生的13-羟基过氧化物中间体，由过氧化物裂解酶形成。12-oxo-9(Z)-Dodecenoic acid (100 µM) 对植物病原真菌 P. parasitica 有活性。
T37867	9(S)-HpOTrE
	9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions. 9(S)-HpOTrE also serves as a substrate for further oxidation by both soybean and potato LOs, resulting in the formation of 9,16-dihydroperoxy acid. The suicide inactivation of LOs when 9(S)-HpOTrE is used as a substrate is thought to oc...
T36099	Jacaric Acid
	Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conju...
T37394	13(S)-HpOTrE
	13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.[1] Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes the formation of both 9- and 13-HpOTrE in a molar ratio of 10:1.1 In plants, 13(S)-HpOTrE can be metabolized by the hydroperoxide lyase pathway producing aldehyde and oxoacid fragments, or by the hydroperoxide dehydratase pathway producing jasmonic acid.[2],[3],[4] Treatment of to...
T37396	13-epi-12-oxo Phytodienoic Acid
	13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 polyunsaturated fatty acids in plants are substrates for plant lipoxygenases. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and major isomer of 12-oxo PDA contains side chains in the cis position, both being β to the ring, the upper side chain attached at C-13, can and fr...

化合物

α-Linolenic Acid (sodium salt)

Cat.No: T35417

Dihomo-γ-Linolenic acid methyl ester

Cat.No: T41323

Target: Others

γ-Linolenic acid ethyl ester

Cat.No: T41235

(±)-Jasmonic acid

Cat.No: T40880

A1-Phytoprostane-I

Cat.No: T36170

Synonym: A1-Phytoprostane-I

Cat.No: T36773

Cat.No: T37865

12-oxo-9(Z)-Dodecenoic Acid

Cat.No: T83761

Synonym: 12-oxo-9-cis-Dodecenoic Acid,12-keto-9Z-Dodecenoic Acid

Cat.No: T37867

Cat.No: T36099

Cat.No: T37394

13-epi-12-oxo Phytodienoic Acid

Cat.No: T37396

Cat. No.	Product Name	Target	Signaling Pathways
T3P2904	α-Linolenic acid Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸，人体无法合成，从种子油中分离得到。它可调节 PI3K/Akt 信号传导，影响血栓形成过程。它具有抗心律失常的特性，并且与心血管疾病和癌症等有关。
TN2374	Methyl Linolenate α-亚麻酸甲酯,Linolenic acid methyl ester,亚麻酸甲酯	Others	Others
	Methyl Linolenate (Linolenic acid methyl ester) 是一种多不饱和脂肪酸。它用于研究不饱和脂肪酸氧化/过氧化的机制和预防。
T78472	Punicic acid Trichosanic acid
	Punicic acid为石榴籽油中存在的一种生物活性化合物，为共轭α-亚麻酸及ω-5多不饱和脂肪酸的异构体，其具备研究慢性疾病潜力。
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

α-Linolenic acid

Cat.No: T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸

Target: Akt, PI3K

Methyl Linolenate

Cat.No: TN2374

Synonym: α-亚麻酸甲酯,Linolenic acid methyl ester,亚麻酸甲酯

Target: Others

Cat.No: T78472

Synonym: Trichosanic acid

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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