首页工具

登录

GM-CSFR alpha Protein, Human, Recombinant (hFc)

产品编号 TMPY-00816

别名: CSF2RAX, CSF2R, CD116, CSF2RY, GM-CSF-R-α, GM-CSF-R-alpha, GM-CSF Receptor α Protein, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage), 集落刺激因子, CSF2RAY, GMCSFR, GMR, SMDP4, CSF2RX, CDw116, colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage)

GM-CSFR alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.2 kDa and the accession number is P15509-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

TargetMol

GM-CSFR alpha Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 24,900		5日内发货

大包装超大折扣，点击咨询

更多批次查询请联系客服

生物活性

技术参数

产品性质

参考文献

生物活性	Measured by its ability to inhibit GM-CSF dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 10-15 μg/ml.
产品描述	GM-CSFR alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.2 kDa and the accession number is P15509-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P15509-1
别名	CSF2RAX, CSF2R, CD116, CSF2RY, GM-CSF-R-α, GM-CSF-R-alpha, GM-CSF Receptor α Protein, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage), 集落刺激因子, CSF2RAY, GMCSFR, GMR, SMDP4, CSF2RX, CDw116, colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage)
蛋白构建	The extracellular domain (Met 1-Gly 320) of Human GM-CSFRα (NP_006131.2) pro-protein was expressed with the C-terminal fused Fc region of Human IgG1.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	61.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.

参考文献

1. Sjöblom C,et al.(2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23. 2. Goldstein JI,et al.(2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16. 3. Saulle E,et al.(2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.

计算器

复溶计算器

重组蛋白稀释计算器

比活力计算器

Volume (to add to vial)

=

Mass (in vial)

÷

Desired Reconstitution Concentration

bottom

技术支持

您可能有的问题的答案可以在重组蛋白操作手册中找到

Keywords

GM-CSFR alpha Protein, Human, Recombinant (hFc) CSF2RAX CSF2R CD 116 SMDP 4 CD116 CSF2RY GM-CSF-R-α GM-CSF-R-alpha GM-CSF Receptor α Protein colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 集落刺激因子 CSF2RAY granulocyte-macrophage GMCSFR GMR SMDP4 CSF2RX CDw116 colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage) SMDP-4 CD-116 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

陶术

生物

TargetMol^®中国区唯一合作伙伴

点击进入陶术生物官网

陶术生物

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼