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TGFBR2 Protein, Human, Recombinant (His)

产品编号 TMPY-05157

TGFBR2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P37173.

TGFBR2 Protein, Human, Recombinant (His)

产品编号 TMPY-05157

TGFBR2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P37173.

规格	价格	库存
100 μg	¥ 3,170	In stock
200 μg	¥ 6,200	5日内发货
500 μg	¥ 14,900	5日内发货

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产品信息

生物活性	Measured by its binding ability in a functional ELISA. Immobilized TGFBR2h (1-166Q) at 10 μg/mL (100 μL/well) can bind TGFB1-His/Biotin , the EC50 of human TGFB1-His/Biotin is 130-300 ng/mL.
产品描述	TGFBR2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P37173.
种属	Human
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	P37173
别名	transforming growth factor, β receptor II,transforming growth factor, beta receptor II (70/80kDa),TGFβ-RII,TGFR-2,TGFbeta-RII,TAAD2,RIIC,MFS2,LDS2B,LDS2,LDS1B,FAA3,AAT3
蛋白构建	A DNA sequence encoding the human TGFBR2 (NP_003233.4) (Met1-Gln166) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Thr 23
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	17.8 kDa (predicted); 24 kDa (reducing condition, due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PBS, 150 mM NaCl, 10% glycerol, 0.5 mM TCEP, pH 7.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.