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N-Acetyl-D-galactosamine

N-Acetyl-D-galactosamine

产品编号 T5885   CAS 14215-68-0
别名: GalNAc, 2-乙酰胺基-2-脱氧-D-半乳糖

N-Acetyl-D-galactosamine (GalNAc) 是一种源自半乳糖的末端必需氨基糖,在人体中形成​​ A 型血的抗原。

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N-Acetyl-D-galactosamine Chemical Structure
N-Acetyl-D-galactosamine, CAS 14215-68-0
规格 价格/CNY 货期 数量
1 mg ¥ 126 现货
5 mg ¥ 245 现货
10 mg ¥ 342 现货
25 mg ¥ 583 现货
50 mg ¥ 875 现货
100 mg ¥ 1,310 现货
200 mg ¥ 1,960 现货
其他形式的 N-Acetyl-D-galactosamine:
产品目录号及名称: N-Acetyl-D-galactosamine (T5885)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans.
体外活性 N-Acetyl-D-galactosamine (GalNAc or D-GalNAc) on the damage induced by SBA on the membrane permeability and tight junction proteins of piglet intestinal epithelium (IPEC-J2) cells. The IPEC-J2 cells were pre-cultured with 0, 0.125 × 10-4 , 0.25 × 10-4 , 0.5 × 10-4 , 1.0 × 10-4 and 2.0 × 10-4 mmol/L GalNAc at different time period (1, 2, 4 and 8 hr) before being exposed to 0.5 mg/ml SBA for 24 hr.Pre-incubation with GalNAc mitigates the mechanical barrier injury as reflected by a significant increase in trans-epithelial electric resistance (TEER) value and a decrease in alkaline phosphatase (ALP) activity in cell culture medium pre-treated with GalNAc before incubation with SBA as both indicate a reduction in cellular membrane permeability. In addition, mRNA levels of the tight junction proteins occludin and claudin-3 were lower in the SBA-treated groups without pre-treatment with GalNAc. The mRNA expression of occludin was reduced by 17.3% and claudin-3 by 42% (p < 0.01). Moreover, the corresponding protein expression levels were lowered by 17.8% and 43.5% (p < 0.05) respectively. However, in the GalNAc pre-treated groups, occludin and claudin-3 mRNAs were reduced by 1.6% (p > 0.05) and 2.7% (p < 0.01), respectively, while the corresponding proteins were reduced by 4.3% and 7.2% (p < 0.05). In conclusion, GalNAc may prevent the effect of SBA on membrane permeability and tight junction proteins on IPEC-J2s.
别名 GalNAc, 2-乙酰胺基-2-脱氧-D-半乳糖
分子量 221.21
分子式 C8H15NO6
CAS No. 14215-68-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 125 mg/mL (565.07 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5206 mL 22.603 mL 45.2059 mL 113.0148 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL 22.603 mL
10 mM 0.4521 mL 2.2603 mL 4.5206 mL 11.3015 mL
20 mM 0.226 mL 1.1301 mL 2.2603 mL 5.6507 mL
50 mM 0.0904 mL 0.4521 mL 0.9041 mL 2.2603 mL
100 mM 0.0452 mL 0.226 mL 0.4521 mL 1.1301 mL

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参考文献

1. Zhao B, Che D, Adams S,et al.N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells[J].J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206.

相关化合物库

该产品包含在如下化合物库中:
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剂量换算

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

N-Acetyl-D-galactosamine 14215-68-0 Others GalNAc 2-乙酰胺基-2-脱氧-D-半乳糖 NAcetylDgalactosamine N Acetyl D galactosamine Inhibitor inhibitor inhibit

 

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