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抑制剂&激动剂
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TargetMol产品目录中 "transcription factor 4"的结果
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TargetMol产品目录中 "

transcription factor 4

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  • 抑制剂&激动剂
    15
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    22
    TargetMol | Recombinant_Protein
  • 天然产物
    3
    TargetMol | Natural_Products
  • 检测抗体
    13
    TargetMol | Antibody_Products
  • OAC3
    4-fluoro-N-(1H-indol-5-yl)benzamide
    T21813182564-41-6
    OAC3 (4-fluoro-N-(1H-indol-5-yl)benzamide) 是八聚体结合转录因子 4 的激活剂。
    • ¥ 193
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Oroxylin A
    千层纸素A, Baicalein 6-methyl ether, 6-Methoxybaicalein
    T6S1315480-11-5
    Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。
    • ¥ 188
    In stock
    规格
    数量
  • PNU-74654
    T7204113906-27-7
    PNU 74654是一种Wnt β-catenin 通路抑制剂,在NCI-H295 细胞中的IC50值为129.8 μM。
    • ¥ 172
    In stock
    规格
    数量
  • RV01
    T127811016897-10-1
    RV01 是一种新型的白藜芦醇喹啉取代类似物,可抑制 DNA 损伤,降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达,具有清除羟自由基的活性。RV01 降低 iNOS 的表达,具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌,抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化,降低toll 样受体4 (TLR4)的蛋白表达,抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
    • ¥ 557
    In stock
    规格
    数量
  • SBI-477
    T12853781628-99-7
    SBI-477 是化学探针,能够使转录因子MondoA 失活,刺激胰岛素信号传导,使胰岛素途径抑制剂硫氧还蛋白相互作用蛋白和抑制蛋白结构域 4 的表达降低。它能够协调地抑制三酰基甘油酯合成,促进人骨骼肌细胞中的基础葡萄糖摄取。
    • ¥ 1580
    In stock
    规格
    数量
  • Toxoflavin
    毒黄素, Xanthothricin, Toxoflavine, PKF-118-310
    T1714284-82-2
    Toxoflavin (Xanthothricin) 是一种 TCF4 β-catenin 复合物抑制剂,也是一种 KDM4A 抑制剂,有抗肿瘤和抗菌作用。
    • ¥ 387
    In stock
    规格
    数量
  • OAC1
    BAS 00287861
    T2040300586-90-7
    OAC1 (BAS 00287861) 是一种能够激活 Octamer 结合转录因子 4 的化合物。 它提高了 iPSC 重编程效率并加速重编程过程。
    • ¥ 245
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Negletein
    黄芩素-7-甲醚, Baicalein-7-methylether, 7-O-Methylbaicalein
    T2S084329550-13-8
    Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
    • ¥ 745
    In stock
    规格
    数量
  • (E)-Guggulsterone
    T3656339025-24-6
    Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR bothin vitroandin vivo.4Thecisstereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50value of 15 μM.5,6By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.4 1.Makishima, M., Okamoto, A.Y., Repa, J.J., et al.Identification of a nuclear receptor for bile acidsScience2841362-1365(1999) 2.Barbier, O., Torra, I.P., Sirvent, A., et al.FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activityGastroenterology1241926-1940(2003) 3.Tan, K.P., Yang, M., and Ito, S.Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressMol. Pharmacol.72(5)1380-1390(2007) 4.Urizar, N.L., Liverman, A.B., Dodds, D.T., et al.A natural product that lowers cholesterol as an anatagonist ligand for FXRScience296(5573)1703-1706(2002) 5.Cui, J., Huang, L., Zhao, A., et al.Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pumpThe Journal of Biological Chemisty278(12)10214-10220(2003) 6.Wu, J., Xia, C., Meier, J., et al.The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptorMolecular Endocrinology16(7)1590-1597(2002)
    • ¥ 483
    5日内发货
    规格
    数量
  • Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
    T366271234494-75-7
    Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.
    • ¥ 457
    待询
    规格
    数量
  • Tonantzitlolone
    T68582845811-30-5
    Tonantzitlolone is a natural agonist of tprc1 4 5 channels, also acting as a dual pkcα and pkcθ activator, inducing an insulin resistant phenotype by inhibiting irs1 and the pi3k akt pathway, activating the heat shock factor 1 (hsf1) transcription factor driving glucose dependency
    • 待询
    10-14周
    规格
    数量
  • APTO-253 HCl
    T702731691221-67-6
    APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
    • ¥ 10600
    1-2周
    规格
    数量
  • APTO-253 isomer
    T707061422826-80-9
    APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
    • ¥ 10600
    6-8周
    规格
    数量
  • E235
    E-235, E 235
    T78077891894-69-2
    E235 是一种调控转录因子4(ATF4)激活剂,具有抗增殖活性。E235 通过启动综合应激反应(ISR)和DNA损伤应答信号来发挥作用。
    • ¥ 542
    In stock
    规格
    数量
  • Kartogenin sodium
    KGN sodium
    T867781401168-39-5
    Kartogenin (KGN) sodium 是一种软骨样组织形成的诱导剂 (EC50: 100 nM)。Kartogenin sodium 通过结合纤维蛋白 A,阻断其与转录因子核心结合因子 β 亚基 (CBFβ) 的作用,并调节 CBFβ-RUNX1 转录程序来诱导软骨形成。此外,Kartogenin sodium 能促进肌腱-骨连接处 (TBJ) 的伤口愈合,因其能刺激胶原蛋白合成。广泛应用于再生医学中的无细胞疗法,Kartogenin sodium 用于软骨再生及保护、腱骨愈合、伤口愈合与肢体发育等方面,同时对骨关节炎 (OA) 的研究也颇具价值。
    • 待询
    10-14周
    规格
    数量
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