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TargetMol产品目录中 "

sting agonist-3

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  • 抑制剂&激动剂
    16
    TargetMol | Inhibitors_Agonists
  • STING agonist-3
    T130142138299-29-1
    STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
    • 待估
    35日内发货
    规格
    数量
  • STING agonist-3 trihydrochloride
    STING agonist-3 trihydrochloride (2138299-29-1 free base)
    T13014L
    STING agonist-3 trihydrochloride is a selective and non-nucleotide agonist of small-molecule STING(pEC50 and pEC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
    • 待询
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    数量
  • STING agonist-30
    T748092951078-67-2In house
    STING agonist-30 是一种高效的 STING 激动剂,能激发STING依赖的免疫激活。STING agonist-30 对包括HSV(单纯疱疹病毒)、轮状病毒及SARS-CoV-2(严重急性呼吸系统综合症冠状病毒2)在内的多种病毒显示出广谱抑制效果。
    • ¥ 1980 TargetMol
    In stock
    规格
    数量
  • STING agonist-31
    T751612719001-44-0
    STINGagonist-31 是一种 STING 激动剂,对 h-STING 和 m-STING 的 EC50值为 0.24 和 39.51 μM。STINGagonist-31 具有抗肿瘤功效。
    • 待询
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  • STING agonist-33
    T874462591300-32-0
    STINGagonist-33 (example 1) 是一种基于 4-乙基-2-甲基噻唑-5-羧酸的 STING (干扰素基因刺激剂) 激动剂。
    • 待询
    待询
    规格
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  • STING agonist-35
    T877222228891-94-7
    STINGagonist-35 (Compound 1a) 是干扰素基因刺激剂 (STING) 的激动剂,激活野生型 STING 和突变型 STING (R232H),激活率分别为 99% 和 92%。STINGagonist-35 有潜力成为 ADC 药物的有效载荷。
    • 待询
    10-14周
    规格
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  • diABZI STING agonist-1 (Tautomerism)
    diABZI STING agonist (Compound 3)
    T110352138498-18-5
    diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂,其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。
    • ¥ 1130
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • MSA-2
    T8798129425-81-6
    MSA-2 是可口服的非核苷酸 STING 激动剂,MSA-2 的非共价体系二聚体与 STING 纳摩尔亲和力结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性,与抗 PD-1 协同作用,可刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫。[3]
    • ¥ 987
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • diABZI-V/C-DBCO
    T200187
    diABZI-V C-DBCO(Compound 3)作为一种高效的STING激动剂,通过组织蛋白酶B的作用释放diABZI-胺,激活STING,从而使干扰素及其他免疫激活分子的生成得以提高,有效增强免疫系统对肿瘤的攻击能力。在THP1-Dual细胞中,diABZI-V C-DBCO与diABZI-胺激活STING的EC50值分别为1.47 nM和0.144 nM;在原代小鼠脾细胞中,这些值分别为7.7 μM和0.17 μM。因此,diABZI-V C-DBCO在癌症免疫研究领域具有重要的应用价值。
    • 待询
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  • cAIMP
    CL-592, CL592, CL 592, CHEMBL4776666
    T2020101507367-51-2
    cAIMP作为STING激动剂,在体外的哺乳动物细胞中,与标准的小鼠(DMXAA)和人类(2',3'-cGAMP)STING激动剂相比,cAIMP类似物能更强烈地激活STING依赖的IRF和NF-κB信号通路。在人类血液的离体实验中,它们能诱导I型干扰素(IFNs)和促炎细胞因子的产生。
    • 待询
    10-14周
    规格
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  • CAY10748
    CAY10748
    T364612412902-55-5
    CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 μM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg. 1.Xi, Q., Wang, M., Jia, W., et al.Design, synthesis, and biological evaluation of amidobenzimidazole derivatives as stimulator of interferon genes (STING) receptor agonistsJ. Med. Chem.63(1)260-282(2019)
    • 待估
    35日内发货
    规格
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  • STING Agonist C11
    STING Agonist C11
    T38161875863-22-2
    STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR).References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018). STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α β receptor (IFNAR). References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018).
    • 待估
    35日内发货
    规格
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  • 2',3'-cGAMP-C2-PPA
    2',3'-cGAMP-C2-PPA
    T402242586047-11-0
    2',3'-cGAMP-C2-PPA (45) is a cyclic di-nucleotide that acts as a STING agonist (US20210015941A1). It is a drug-linker conjugate for antibody-drug conjugates (ADC) used in the targeted treatment of cancer.
    • 待询
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  • 3',3'-cGAMP sodium salt
    T41205
    3',3'-cGAMP sodium salt is a STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cellsin vitro. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ-TCL1 mice.
    • 待询
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  • c-di-AMP disodium
    T738732734909-87-4
    c-di-AMP (Cyclic diadenylate) sodium 作为一种STING 激动剂,通过结合STING 激活TBK3-IRF3 信号途径,引发I 型 IFN 和 TNF 产生,兼具细菌第二信使功能,在革兰氏阳性细菌中调控细胞生长、存活及毒力,并影响宿主免疫反应。此外,作为有效的粘膜佐剂,它能刺激体液和细胞反应。
    • ¥ 3180
    35日内发货
    规格
    数量
  • BDW568
    T83901335401-44-0
    BDW568是一种刺激素干扰素基因(STING)的激动剂,同时是BDW-OH的前药形式。在使用THP-1细胞的报告基因测定中,它能诱导STING转录活性(EC50 = 7.6 µM)。BDW568(50 µM)在THP-1细胞中诱导TANK结合激酶1(TBK1)和IFN调节因子3(IRF3)的磷酸化。
    • 待估
    35日内发货
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