spt-in-1

SPT-IN-1 is an inhibitor of potent serine palmitoyl transferase (SPT).

Nicotinamide-d4是Nicotinamide的氘代标记化合物，可用于同位素示踪。Nicotinamide是一种维生素B3的衍生物，是SIRT1和SIRT2的抑制剂。

ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

SGF29-IN-1 (Compound Cpd_DC60) 作为一种选择性抑制剂，专门针对 Spt-Ada-Gcn5 乙酰转移酶 (SAGA) 相关因子 29 (SGF29)-Tudor 结构域。该化合物展现了对抗白血病的潜力。