spr

SPI 112 是一种选择性的、有效的、竞争性的SHP2 (PTPN11)抑制剂，对SHP2，蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的IC50分别为 1 μM，18.3 μM 和 14.5 μM。

SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.

SPR719 is an inhibitor of gyrase B, has bactericidal activity.

SPR inhibitor 3是一类用于抑制Sepiapterin reductase活性的小分子化合物，可阻断四氢生物蝶呤（BH4）的生物合成途径，影响一氧化氮合酶及单胺类神经递质的生成。

SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetate effectively combats bacterial infections. Notably, SPR206 acetate demonstrates significant efficacy with minimum inhibitory concentration (MIC) values of 0.125 mg/L against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301.

SPR-00305 is a novel potent inhibitor of the mvfr pathway

Spr 210 is an aldose reductase (AR) inhibitor with potential uses as a therapeutic agent for preventing and improving some diabetic complications.

SPR741 TFA (NAB741 TFA) is a cationic peptide derived from polymyxin B and is a potentiator molecule.

SPR741, formerly NAB741 (12), is a cationic peptide derived from polymyxin B and is one such potentiator molecule that is under development for the treatment of serious Gram-negative bacterial infections.

SPR741 acetate 是衍生自多粘菌素 B 的阳离子肽，通过增加革兰氏阴性细菌外膜的通透性来抑制严重的革兰氏阴性细菌感从而展现出对革兰氏阴性菌的抗菌活性。SPR741 acetate 常与抗生素联合使用来治疗一些疾病。

SPR7 是有效的、选择性的 rhodesain 抑制剂 (Ki: 0.51 nM)。SPR7 对 T. b. brucei 表现出抗寄生虫效果 (EC50: 1.65 μM)。

SPR519 is a potent dual inhibitor of PI3Kα and mTOR kinases with IC50 (PI3Kalpha) = 30 nM and IC50 (mTOR) = 10 nM. SPR519 exhibits an EC50 of low sub-micromolar range among various tested cancer cell lines such as A2780 (0.23 μM), PC3 (0.48 μM), and SKOV3 (0.50 μM).

SPR39 是一种有效的 SARS-CoV-2 主要蛋白酶抑制剂，对 SARS-CoV-2 Mpro, hCatL, hCatB 的 Ki 值分别为 0.252、3.38、7.88 µM。SPR39 具有抗病毒和细胞毒性。

SPR38 是一种有效的 SARS-CoV-2 主要蛋白酶 (SARS-CoV-2 main protease) 抑制剂，Ki 为 0.260 μM。SPR38 还抑制hCatL 和hCatB，Ki 值分别为 1.92 μM 和 11.1 μM。

SPR41 是一种有效的 SARS-CoV-2 主要蛋白酶抑制剂，对 SARS-CoV-2 Mpro, hCatL, hCatB 的 Ki 值分别为 0.184, 0.252, 14.4 µM。SPR41 具有抗病毒和细胞毒性。

SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.

Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486). Fobrepodacin has potent bactericidal activities in vivo.

Ibrexafungerp citrate 是一种三萜类抗真菌药物，可抑制真菌细胞壁中 1,3-β-D-葡聚糖的合成。尽管其功能结果与棘白菌素类相似，但其结合于葡聚糖合酶的不同位点，从而具有有限的交叉耐药性。Ibrexafungerp citrate 对念珠菌属表现出浓度依赖性的杀真菌活性，并对多数氟康唑耐药菌株保持较强的体外活性，支持其在抗真菌耐药性和药物开发研究中的应用。

Pateamine A is a marine macrolide that is isolated from the sponge Mycale hentscheli and exhibits anticancer and antiviral properties. It has a role as a marine metabolite, an antiviral agent, an antineoplastic agent, and a eukaryotic initiation factor 4F inhibitor. It is a macrolide, a member of 1,3-thiazoles, a tertiary amino compound, a primary amino compound, and an olefinic compound. Pateamine A an inhibitor of eukaryotic translation.

Esprolol (ACC-9369 free base) 是一种新的 β 肾上腺素能受体拮抗剂，可用于研究劳力性心绞痛。

Ispronicline (TC-1734) 是一种具有口服活性、选择性和有效性的 α4β2 nAChR 部分激动剂，具有抗抑郁、神经保护和持久的认知作用。Ispronicline 对 α4β2 nAChR 具有很高的亲和力，Ki= 11 nM。

SPRC is a novel synthetic molecule exerting antioxidant effects via elevating the generation of endogenous H2S. SPRC activates Gp130-mediated STAT3 and prevents doxorubicin-induced cardiotoxicity.

Esprocarb 是一种用于水稻的苗前和苗后除草剂 (herbicide)。

Esprolol is a β-adrenergic receptor antagonist.