spdp

SPDP 是一种短链交联剂，用于通过 NHS 酯和吡啶基二硫醇反应基团与半胱氨酸巯基形成可切割（可还原）的二硫键，实现胺与巯基的共轭。它是一种可降解的 ADC 连接剂，可用于合成抗体偶联药物。

LC-PEG8-SPDP is a cleavable ADC linker utilized in antibody-drug conjugates (ADCs) [1].

SPDP-C6-NHS ester is an alkyl ether-based linker utilized in the synthesis of PROTACs[1].

SPDP-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG4-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG6-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

PC SPDP-NHS carbonate ester is a cleavable linker compound utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-C6-Gly-Leu-NHS ester is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG12-acid is a cleavable 12-unit polyethylene glycol (PEG) linker utilized for the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG12-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG24-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG24-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG36-NHS ester is a PEG ADC linker consisting of 36 units, characterized by cleavability. It plays a crucial role in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG5-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG7-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG9-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Sulfo-LC-SPDP is a heterobifunctional crosslinker characterized by its thiol-cleavable and membrane impermeable properties.

Sulfo-SPDP-C6-NHS sodium is a sodium salt form of a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-sulfo is a cleavable linker vital in ADC synthesis. SPDP-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

DSPE-SPDP，一种磷脂分子，能够在水中自行定向并形成脂质双层，适用于多种生化研究。

Ald-PEG23-SPDP 是一种含 23 个单元 PEG 的可降解 (cleavable) ADC linker，用于合成抗体偶联活性分子 (ADC)。

PLLA5000-PEG5000-SPDP 是一种聚乳酸衍生物，能够在水中形成胶束，其中的 SPDP 部分可与硫醇发生反应，适用于药物递送的研究。

PLLA5000-PEG3000-SPDP 是一种聚乳酸衍生物，在水中能够形成胶束，其中的 SPDP 部分可与硫醇发生反应。该化合物可用于药物递送研究。