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抑制剂&激动剂
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  • 抑制剂&激动剂
    18
    TargetMol | Inhibitors_Agonists
  • 染料试剂
    4
    TargetMol | Dye_Reagents
  • 天然产物
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    TargetMol | Natural_Products
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    TargetMol | Disease_Modeling_Products
  • Uric Acid
    尿酸, Urate, Lithic acid, 2,6,8-Trioxypurine, 2,6,8-Trioxopurine, 2,6,8-Trihydroxypurine
    T062669-93-2
    Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ,如单线态氧和过氧亚硝酸盐,抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
    • ¥ 153
    In stock
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    数量
  • 2,4,6-Trimethylphenol
    Mesitol, 2,4,6-三甲基苯酚
    T40607527-60-6
    2,4,6-Trimethylphenol (Mesitol) 是一种与有机物 (3DOM*) 反应的探针化合物,可在水溶液中被单线态氧快速氧化。
    • ¥ 147
    In stock
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  • Uric acid sodium
    尿酸钠
    T412421198-77-2
    Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂,是一种有效的、常见的抗氧化剂,有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS),如单线态氧和过氧亚硝酸盐,对脂质过氧化有抑制作用,与痛风性关节病的发病机理和草酸钙结石的形成有关。
    • ¥ 113
    In stock
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  • TMB dihydrochloride x.hydrate
    Sure Blue TMB dihydrochloride x.hydrate
    T200186207738-08-7
    TMB(dihydrochloride x.hydrate) 代表TMB的一种二盐酸盐x水合物形式。这种化合物是一种无毒且不致突变的无色染料,常用作基于辣根过氧化物酶检测系统的显色剂。此外,TMB(dihydrochloride x.hydrate) 能够作为活性氧和氮物质(ROS RNS)光声探针,与次氯酸盐、过氧化氢、单线态氧和二氧化氮反应,产生蓝色的氧化产物。它还可用于检测大肠杆菌ATCC 25922细胞外膜产生的单线态氧。
    • ¥ 10600
    2-4周
    规格
    数量
  • YRN84347
    YRN 84347, meso-Tetra (3,5-dimethoxyphenyl) porphine, 5,10,15,20-tetrakis(3,5-dimethoxyphenyl)porphyrin, YRN-84347
    T20256574684-34-7
    YRN84347,即meso-Tetra (3,5-dimethoxyphenyl) porphine,是一种合成的卟啉产品和光敏剂。该化合物展示了较高的单线态氧产率,揭示了其在光动力治疗癌症及其他相关人类疾病中的潜在应用。
    • 待询
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  • NFh-NMe-2
    T204458
    NFh-NMe-2 是一种光敏剂,能够与硝基还原酶 (nitroreductase) 结合,在肿瘤细胞中生成单线态氧,展现出细胞毒性并诱导细胞凋亡 (apoptosis)。在小鼠模型中,NFh-NMe-2 显示出抗肿瘤活性。
    • 待询
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  • Parabanic acid
    NSC-9789, NSC9789, NSC 9789
    T20548120-89-8
    Parabanic acid is the oxidation product of uric acid by singlet oxygen.
    • ¥ 10600
    待询
    规格
    数量
  • Rostaporfin
    tin etiopurpurin dichloride, tin ethyl etiopurpurin dichloride, SnET2, Sn(IV) etiopurpurin, Purlytin
    T34393284041-10-7
    Rostaporfin (also known as REM-001, tin ethyl etiopurpurin, Sn(IV) etiopurpurin, Purlytin, SnET2), is a synthetic purpurin with photosensitizing activity. Rostaporfin preferentially accumulates in tumor cells due to an increased rate of metabolism. Upon e
    • ¥ 10600
    6-8周
    规格
    数量
  • AMK (hydrochloride)
    T361761215711-91-3
    AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7 macrophages when used at a concentration of 500 μM.2,3AMK (20 mg kg) decreases MPTP-induced increases in lipid peroxidation in the cytosol and mitochondria from substantia nigra and striatum in a mouse model of MPTP-induced Parkinson’s disease.4 1.Schaefer, M., and Hardeland, R.The melatonin metabolite N1-acetyl-5-methoxykynuramine is a potent singlet oxygen scavengerJ. Pineal Res.46(1)49-52(2009) 2.Kelly, R.W., Amato, F., and Seamark, R.F.N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesisBiochem. Biophys. Res. Commun.121(1)372-379(1984) 3.Mayo, J.C., Sainz, R.M., Tan, D.-X., et al.Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophagesJ. Neuroimmunol.165(1-2)139-149(2005) 4.Tapias, V., Escames, G., López, L.C., et al.Melatonin and its brain metabolite N1-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian miceJ. Neurosci. Res.87(13)3002-3010(2009) 5.Tan, D.-X., Manchester, L.C., Reiter, R.J., et al.Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic pathway of melatonin biotransformationFree Radic. Biol. Med.29(11)1177-1185(2000) 6.Hirata, F., Hayaishi, O., Tokuyama, T., et al.In vitro and in vivo formation of two new metabolites of melatoninJ. Biol. Chem.249(4)1311-1313(1974)
    • ¥ 770
    35日内发货
    规格
    数量
  • Transcrocetin
    藏红花酸, trans-Crocetin
    T4S017127876-94-4
    Transcrocetin (8,8'-Diapocarotenedioic Acid) 是来源于藏红花 (Crocus sativus L.) 的活性化合物,是一种能够透过血脑屏障的,高亲和力的NMDA 受体拮抗剂。
    • ¥ 413
    In stock
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    数量
  • Benz-AP
    T746292416220-53-4
    Benz-AP 是一种高效光敏剂,能产生单线态氧并与 hCES2 活性呈负相关。在 hCES2 低表达的癌细胞中,Benz-AP 表现出较高的光毒性。采用双光子激发(TPE)技术,Benz-AP 能够生成 ROS,有效杀死癌细胞和肿瘤球体。
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  • 4-Thiouracil
    2-hydroxy-4-Mercaptopyrimidine,4-Thiopyrimidin-2-one,NSC 43288,4-TU
    T84403591-28-6
    4-Thiouracil is a photoactivatable probe designated for site-specific applications in detecting RNA structures and nucleic acid-nucleic acid contacts. Upon illumination with ultraviolet light exceeding 300 nm and in the presence of oxygen, it serves as an energy donor, facilitating the generation of singlet oxygen through triplet-triplet energy transfer. This process enables the highly reactive oxygen species to interact with 4-thiouracil, leading to the formation of uracil and uracil-6-sulfonate; the latter exhibits fluorescence around a wavelength of approximately 390 nm. Additionally, 4-Thiouracil functions as a substrate for T. gondii uracil phosphoribosyltransferase, allowing the synthesis of 4-thiouridine monophosphate for subsequent integration into RNA.
    • 待询
    8-10周
    规格
    数量
  • NFh-ALP
    T89415
    NFh-ALP 作为一种碱性磷酸酶 (ALP) 激活的光敏剂,其最大吸收波长为656 nm.在细胞内,NFh-ALP 通过 ALP 的作用被激活,并在808 nm的光激发下产生单线态氧1O2,从而有效杀死肿瘤细胞,主要是通过诱导细胞凋亡实现,并表现出良好的生物相容性.
    • 待询
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  • Dehydroglyasperin D
    TMA0291517885-72-2
    Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
    • ¥ 11700
    6-8周
    规格
    数量
  • 4-Allylcatechol
    Hydroxychavicol, 4-Allylpyrocatechol, 2-羟基胡椒酚
    TN12741126-61-0
    4-Allylcatechol (Hydroxychavicol) 是合成黄樟素的一种中间体。
    • ¥ 108
    In stock
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    数量
  • Isoangustone A
    TN4263129280-34-8
    Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
    • ¥ 1590
    In stock
    规格
    数量
  • Pallidol
    1622292-61-8, Pallidol A, Rel-Pallidol
    TN6584105037-88-5
    Pallidol (Pallidol A) 是一种可从红葡萄酒中提取的白藜芦醇二聚体,是一种选择性单线态氧淬灭剂,具有抗氧化和抗真菌活性。
    • ¥ 5500
    待询
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    数量
  • 5-Methoxysterigmatocystin
    TN787722897-08-1
    5-Methoxysterigmatocystin 是一种具细胞毒性和遗传毒性的霉菌毒素。它对癌细胞 A549 和 HepG2 展现细胞毒性,IC50分别为 5.5 和 0.7 μM,并且会引发 DNA 损伤。5-Methoxysterigmatocystin 还是一种光敏剂,能够在可见光作用下生成单线态氧 (1O2)。
    • 待询
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