sgc-7901

Quinacrine dihydrochloride (Mepacrine dihydrochloride) 是一种具有口服活性的抗疟剂，抑制 NF-κB 并激活 p53 信号转导，诱导肿瘤细胞发生凋亡，具有抗肿瘤和抗寄生虫活性。

Sertindole (Lu 23-174) 是一种非典型抗精神病药，可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合，Kd 值分别为 2.7、20、0.14 和 6 nM。

Imatinib Mesylate (STI571 Mesylate) 是一种多靶点受体酪氨酸激酶抑制剂，可选择性抑制 BCR ABL、v-Abl、PDGFR、c-kit 等激酶活性，具有口服活性。Imatinib Mesylate 具有抗肿瘤活性，可用于治疗慢性粒细胞白血病。

H1k 是一种 eudistomin Y 荧光衍生物和溶酶体靶向抗增殖剂。它可以剂量依赖性地增加自噬信号，下调细胞周期蛋白依赖性激酶(cyclin-dependent kinase, CDK1)和细胞周期蛋白 B1的表达。

Dihydroartemisinin (Artenimol) 是一种抗疟疾药物。

GSK126 (GSK2816126A) 是一种 EZH2 甲基转移酶抑制剂 (IC50=9.9 nM)，具有有效性和选择性。GSK126 具有抗肿瘤活性，可以抑制肿瘤细胞增殖、抑制血管生成。

Antiproliferative agent-59（Compound 14u）作为一种微管蛋白 (tubulin) 聚合抑制剂，显示了对多种癌细胞线如Huh7、SGC-7901 和 MCF-7的显著抗增殖效果，其 IC50 值分别为 0.03、0.18 和 0.13 μM。此化合物能在 G2 M 期阻断细胞周期，并在 Huh7 细胞中触发细胞凋亡 (apoptosis)。在 Huh7 异种移植小鼠模型中，Antiproliferative agent-59 对肝癌具备抗肿瘤活性，并未观察到显著的毒副作用。

Tubulin polymerization-IN-30 (compound 6e) 是有效的微管蛋白聚合 (Tubulin polymerization) 抑制剂，可破坏细胞内微管组织，将细胞周期阻滞在 G2 M 期。Tubulin polymerization-IN-30 对 HeLa、SGC-7901和A549 等肿瘤细胞系具有良好的抗肿瘤活性，其IC50分别为 0.403、 2.16和2.21 μM。

Tubulin aggregation-IN-16 (compound 5g) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-16 对癌细胞有效 (IC50: 0.084-0.221 μM)。Tubulin aggregation-IN-16 能有效地破坏微管 管蛋白的动态，诱导 SGC-7901 细胞的细胞周期阻滞在 G2 M 期。

β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 µg ml, respectively). It also inhibits cAMP phosphodiesterase with an IC50 value of 96 µM.

Cytoglobosin C, 作为一种细胞松弛素衍生物，对SGC-7901和A549细胞系展现出显著的细胞毒性，IC50值均小于10 μM。

MY-1076 是一种高效的 YAP 抑制剂，具有抗胃癌活性。MY-1076 剂量依赖性诱导G2 M期阻滞，诱导 YAP 降解和细胞凋亡，抑制微管蛋白聚合。MY-1076 抑制 MGC-803、SGC-7901、HCT-116 和 KYSE450 细胞增殖。

c-Met-IN-19（Compound 21j）作为c-Met抑制剂，呈现出对A549、HT-29、SGC-7901、MDA-MB-231细胞系的细胞毒效应，其IC50分别为0.25、0.36、0.98、0.76 μM，并具有较高的抑制活性（IC50: 1.99 nM）。

2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。

Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.

Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation.

Hydroxytanshinone ⅡA has good antiproliferative effect on SGC-7901,HeLa, and HepG 2 cell, the values of IC50 are 4.18, 6.08 and10.20 uM, respectively; it has tumor cell proliferation inhibition significantly stronger than the tanshinoneⅡA.

Ivangustin 是从药用植物 Inula britannica 中提取得到的一种倍半萜内酯，对HEp2、SGC-7901和HCT116人癌细胞系表现出显著的细胞毒性。

Schleicheol 1 has antitumor activity, it possesses inhibitory activity against SGC-7901 cell line.

Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis through mitochondrial dysfunction, and cell cycle arrest at S phase in a dose-dependent manner, it also can increase the production of reactive oxygen species.