N-3-hydroxydecanoyl-DL-Homoserine lactone is a bacterial quorum-sensing molecule.1It activates SdiA (EC50= 0.6 μM), a transcription factor that detects N-acyl homoserine lactones (AHLs), in the 14028 pJNS25 strain ofS. enterica.2 1.Fekete, A., Frommberger, M., Rothballer, M., et al.Identification of bacterial N-acylhomoserine lactones (AHLs) with a combination of ultra-performance liquid chromatography (UPLC), ultra-high-resolution mass spectrometry, and in-situ biosensorsAnal. Bioanal. Chem.387455-467(2007) 2.Janssens, J.C.A., Metzger, K., Daniels, R., et al.Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologueAppl. Environ. Microb.73(2)535-544(2007)
Catalpin exhibited mutagenic activity towards Salmonellatyphimurium strain TA100 in the presence and absence of rat liver homogenate (S9) mix in Ames' test.
Topazolin has weak fungitoxic activity, it displays significant activity against Salmonellatyphimurium ATCC 13311 with MIC values ranging from 2 to 8 ug mL, it also shows in vitro free radical scavenging activities with IC50 values in the range of 0.18-0.56 mg mL.
Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype typhimurium 是来自血清型沙门氏菌的脂多糖内毒素及TLR4激活剂,属于S型LPS。该化合物具有典型的三部分结构:O抗原、核心寡糖和脂质A。它能够调控细菌在树突状细胞(DC)内的命运,影响DC对细菌的摄取、降解和免疫功能的激活。