s. faecalis

Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素，增加了对 β-内酰胺酶的稳定性。

Dermaseptin acetate 是一种从青蛙皮肤中分离出来的肽，在微摩尔浓度下表现出对细菌、真菌和原生动物的有效抗菌活性。

Gentamicin sulfate(SCH9724)是一种广谱和可口服的氨基糖苷类抗生素，对需氧的革兰氏阴性菌具有抑制活性，能够干扰mRNA的翻译。

Sclareolide (Norambreinolide) 是一种从Salvia sclarea 的花中分离得到的天然产物，具有抗菌和细胞毒性作用。

Cefuroxime (Cephuroxime) 是一种具有口服活性的第二代头孢菌素类抗生素，具有抗菌活性，抑制革兰氏阳性菌和革兰氏阴性菌，可用于研究软组织感染。

L-Tyrosine Decarboxylase, Streptococcus faecalis (EC 4.1.1.25) 是一种羧基裂解酶，可裂解碳-碳键。L-Tyrosine Decarboxylase Apoenzyme 参与酪氨酸代谢和生物碱合成，使用辅因子磷酸吡哆醛，底物为L-酪氨酸，生成酪胺和二氧化碳。

L-Phenylalanine decarboxylase, Streptococcus faecalis (EC 4.1.1.53) 是裂解酶家族的成员，能够裂解碳-碳键。该酶参与苯丙氨酸的代谢，以 L-苯丙氨酸为底物，生成苯乙胺和 CO2。

L-Tyrosine Decarboxylase Apoenzyme, Streptococcus faecalis (EC 4.1.1.25) 是一种羧基裂解酶，能够裂解碳-碳键，参与酪氨酸代谢和生物碱的生物合成。该酶使用辅因子磷酸吡哆醛，其底物为 L-酪氨酸，并生成酪胺和二氧化碳作为产物。

Transcarbamylase, Streptococcus faecalis Ornithine (EC 2.1.3.3) 是催化氨甲酰磷酸 (CP) 与鸟氨酸 (Orn) 生成瓜氨酸 (Cit) 和磷酸盐 (Pi) 的酶。

Blasticidin S HCl属于天然产物，是蛋白质合成抑制剂。Blasticidin S HCl是广谱抗生素，可抑制原核生物、真菌、植物和哺乳动物细胞的细胞生长。

Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains(MIC of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively).

Antibacterialagent 256 (Compound C09) 是一种 I 型信号肽酶（SPase I）抑制剂，针对革兰氏阳性菌提供抑制活性。它可有效抑制 S. aureus ATCC 29213、E. faecium QF31、E. faecalis SF23-1 和 S. suis P1/7，MIC 范围为 1-16 μg/mL。在癌细胞 HEp-2 和 Caco-2 中显示出显著的细胞毒性，CC50 分别为 14.65 μg/mL 和 21.93 μg/mL。此外，Antibacterialagent 256 对小鼠红细胞具有溶血活性，HC50 为 13.29 μg/mL，并且能够改善小鼠模型中的 MRSA 皮肤感染。

Gramicidin S 2HCl，是一种抗生素。GS在40-80 μg/mL浓度下可在20-40分钟内减少浮游细胞数量。对于已形成的生物膜，GS在100-200 μg/mL浓度时可有效杀死细胞，并防止再生长。其抗生物膜效果归因于肽的跨膜转运及与核苷酸（例如报警分子ppGpp）复合。GS对E. faecalis引起的抗药性及形成生物膜的感染表现出广泛活性，验证了其在根管治疗中的高效。此外，两位志愿者的顽固性感染根管治疗成功，进一步证实了GS的治疗性能。这些研究表明，GS可以在根管内治疗中得到有效应用。

Antimicrobial agent-35 (Compound c9) 在抑制S. aureus，E. coli，E. faecalis和S. maltophilia方面展现出显著的抗菌活性，其MIC范围为0.5-2 μg/mL。同时，该化合物对HT-22细胞具有一定的细胞毒性，IC50为130.4 μg/mL。

ROS inducer 8 (Compound 11g) 是一种谷胱甘肽 (GSH) 抑制剂，能在粪肠球菌Enterococcus faecalis中诱导ROS积累，展示抗菌活性。该化合物可破坏生物膜，MIC为8 μg/mL对S. aureus有效，对E. faecalis则为2 μg/mL，同时具有后抗生素效应。此外，ROS inducer 8 对绵羊红细胞展现出低溶血毒性（HC50> 1280 μg/mL）。

Florfenicol-propanoate-piperidin (Compound 1) 是 Florfenicol 的一种衍生物，展示了抗菌活性。它能够抑制 E. coli ATCC25922、Salmonella CICC110420、S. aureus ATCC29213、B. subtilis CMCC(B)63501、E. faecalis ATCC29212、S. suis CVCC606 和 Haemophilus parasuis，最低抑制浓度（MIC）为 2-8 μM。

Pyrrofolic acid shows high anti-folate biological activity for S. faecalis.

Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimuriu

10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and teniposide and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 μg/ml, respectively). 10'-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM).

Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34 μg/ml).3

Flumequine-13C3 is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine (T1060) is a fluoroquinolone antibiotic.1It is active againstS. aureus,S. pyogenes,B. subtilis,E. coli,P. aeruginosa,S. faecalis,andK. pneumoniae (MICs = 1-100 μg/ml). Flumequine (T1060) is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase,disrupting supercoiling of bacterial DNA to block transcription and replication.3

Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).

Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM, respectively, in CHO cells expressing the human transporters.3

Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2