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抑制剂&激动剂
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TargetMol产品目录中 "rimonabant"的结果
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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
  • Rimonabant
    利莫那班, SR141716
    T1519L168273-06-1
    Rimonabant (SR141716) 是一种选择性的、能透过血脑屏障的中心大麻素受体 1 拮抗剂, Ki 值为 1.8 nM。它也能够抑制分枝杆菌膜蛋白 3。
    • ¥ 123
    In stock
    规格
    数量
  • Rimonabant hydrochloride
    盐酸利莫那班, SR 151716A, SR 141716A
    T1519158681-13-1
    Rimonabant hydrochloride (SR 141716A) 是中心大麻素受体 1 的高效选择性反向激动剂, Ki 值为1.8 nM。它也能够抑制分枝杆菌膜蛋白3。
    • ¥ 271
    In stock
    规格
    数量
  • N-Aminopiperidine hydrochloride
    Piperidin-1-amine hydrochloride, N-氨基哌啶盐酸盐
    T053363234-70-8
    N-Aminopiperidine hydrochloride (Piperidin-1-amine hydrochloride) 是大麻素受体 1 拮抗剂 Rimonabant(一种抗肥胖剂)的代谢物(M1)。
    • ¥ 173
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • AM-6538
    T378971245626-00-9
    AM6538 is a long-acting, high affinity, and pseudo-irreversible cannabinoid antagonist, structurally analogous to rimonabant. It serves as a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. Additionally, AM6538 holds potential for future investigations that necessitate temporary reductions in cannabinoid receptor availability[1].
    • ¥ 2490
    5日内发货
    规格
    数量
  • (R)-AM1241
    (R)-AM1241
    T38030444912-51-0
    (R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone .
    • 待估
    35日内发货
    规格
    数量
  • (S)-AM1241
    (S)-AM1241
    T38147444912-53-2
    (S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human, rat, and mouse CB2 receptors but shows greater activity at human CB2 (EC50 = 131 nM) than at rat and mouse CB2 receptors (EC50 = 785 and 2,000 nM, respectively). Similar to the racemate AM1241 , (S)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (S)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone .
    • 待估
    35日内发货
    规格
    数量
  • cb1-in-2
    T616092527805-39-4
    CB1-IN-2 (Compound 4g) is a potent and selective inhibitor of the CB1 receptor, exhibiting an IC50 value of 0.644 μM. This compound possesses the ability to penetrate the blood-brain barrier and has the potential to induce central nervous system (CNS) side effects similar to Rimonabant [1].
    • ¥ 10600
    6-8周
    规格
    数量