r 450

Dabuzalgron, an adrenoceptor agonist, is used potentially for the treatment of urinary incontinence.

Itraconazole (R51211) 属于三唑类天然产物，是一种抗真菌剂，具有口服活性。Itraconazole 是一种 Hedgehog 信号通路拮抗剂，一种 oxysterol-binding protein (OSBP) 抑制剂，也是一种细胞色素 P-450 依赖性酶的抑制剂。

(R)-Reticuline（(R)-番荔枝碱）是一种天然生物碱，在动植物体内可以由微粒体 P-450 系统催化转化为 Salutaridine，参与内源性吗啡的合成。(R)-Reticuline的异构体是Reticuline，Reticuline能够抑制JAK2 STAT3和NF-κB信号通路，还能抑制TNF-α和IL-6的mRNA表达，具有抗炎的作用。

(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin , which is the inactive form of (-)-blebbistatin . Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereochemistry as the inactive (+)-blebbistatin enantiomer.