purine riboside

Purine riboside triphosphate, a derivative of purine riboside, exhibits structural similarity to adenosine. This naturally occurring base analog possesses inhibitory effects on carcinogenic growth, particularly in cancer ascites cells, by strongly impeding RNA and DNA synthesis.

Purine riboside-5'-O-triphosphate sodium 是 Nebularine (HY -103694) 的活性代谢产物，作为 DNA 引物酶 ATP 和 GTP 聚合活性的抑制剂，其IC50值分别为 35 µM 和 28 µM。此外，Purine riboside-5'-O-triphosphate sodium 还能抑制钙调素依赖性蛋白激酶II (calmodulin-dependent protein kinase II (CaMKII))，其Ki值为 590 µM。

2-Amino-6-O-methyl-2’-O-methyl purine riboside 是一种嘌呤核苷类似物，以广泛的抗肿瘤活性及靶向惰性淋巴系统恶性肿瘤为特征。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡（apoptosis）实现。

2-Amino-6-O-methyl-2'-O-methyl purine riboside is a Nucleoside Derivative - 6-Modified purine nucleoside, 2'-Modified nucleoside.

6-(Furan-2-yl)purine-beta-D-riboside is a Nucleoside Derivative - 6-Modified purine nucleoside.

2-Chloro-6-(furan-2-yl)purine-beta-D-(3'-deoxy-3'-fluoro)riboside is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purine nucleoside, Halo-nucleoside, 3'-Modified nucleoside; Scaffold and Template.

Nucleoside Derivatives - Fluoro-modified nucleosides; 6-Modified purine nucleosides, 3'-Modified nucleosides

6-Chloro-2-iodopurine-9-riboside is a Halo nucleoside.

Nucleoside - 6-deaminopurine nucleoside

2-Chloro-2'-deoxy-6-O-methylinosine is a Nucleoside Derivative - Halo-nucleoside, 2-Modified purine nucleoside, 6-Modified purine nucleoside.

6-Chloropurine riboside （6-CPR）是一种嘌呤核苷类似物，已被发现具有广泛的生物活性。它可以抑制肿瘤细胞的生长并诱导其凋亡，还被证明具有抗炎、抗病毒和抗真菌的特性，也被发现具有神经保护作用，并已用于治疗神经疾病。

6-Methylmercaptopurine riboside是一种嘌呤核苷类似物，可用于生物化学实验和药物合成研究。

2,6-Dichloro-2',3',5'-triacetyl-purine riboside is a Nucleoside Derivative - Halo-nucleoside; Scaffold and Template.

6-Chloropurine riboside-5'-triphosphate是一种RNA三磷酸酶mRNA-帽化酶β亚单位(Cet1; IC50 = 2 µM，针对S. cerevisiae酶的GTPase活性)的抑制剂，同时也是6-chloropurine riboside的磷酸化形式。此外，它还能激活E. coli天冬氨酸氨甲酰转移酶(EC50 = 0.76 mM)。6-Chloropurine riboside-5'-triphosphate已在合成具有抗癌活性的细胞因子以及一种光点击形式的ATP中得到应用。

Nucleoside Derivatives - Halo-nucleosides, 2'-Modified nucleosides; Scaffolds and Templates

2',3'-O-Isopropylidene-6-mercaptopurine riboside是一种化合物，展现出优异的金属络合活性。此化合物适用于金属络合机理的研究。

Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II.

6-​Thioinosine (6TI) 是一种嘌呤抗代谢物，是抗脂肪形成剂，能降低PPAR γ和C/EBPα及其目标基因 aP2、CD36、LPL 和 LXRα 的 mRNA 水平。

Allopurinol riboside 是别嘌醇的代谢产物，具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用，Ki 为 277 μM。

5-Methyluridine (Thymine riboside) 是发现于人体液中的内源性甲基化核苷。

2-Aminopurine-9-beta-D-(2’-deoxy)riboside 是2-Aminopurine 的衍生物。

2,6-Dichloropurine-9-β-D-riboside is a building block.1,2It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins. 1.Wower, J., Hixson, S.S., Sylvers, L.A., et al.Synthesis of 2,6-diazido-9-(β-D-ribofuranosyl)purine 3',5'-bisphosphate: Incorporation into transfer RNA and photochemical labeling of Escherichia coli ribosomesBioconjug. Chem.5(2)158-161(1994) 2.Seiter, M.S., Bauer, M.P., Bogel, P.D., et al.Synthesis of novel spin-labeled photoaffinity derivatives of NAD+ and ATP and their characterization as coenzymes and substrates of several enzymesSynthesis2269-273(1996)

6-Methoxypurine-9-beta-D-(3-methoxy riboside) 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物，主要针对惰性淋巴系统恶性肿瘤。其机制主要通过抑制 DNA 合成和诱导细胞凋亡（apoptosis）实现。

Riboxin (IDP) 是一种抗缺氧及抗高血压活性的口服有效嘌呤衍生物次黄苷。该化合物对心律失常也具有治疗作用，能够干预Ouabain诱导的猫、兔子、小鼠的心脏节律障碍模型。此外，Riboxin还能保护动物不受γ辐射的损害。