protozoan

Hydroxy Dimetridazole 是Dimetridazol 的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物，可用于对抗原生动物感染。

Chloramphenicol (Chloromycetin) 是一种广谱抗生素，有效抑制细菌蛋白质生物合成。Chloramphenicol 主要作用于细菌 70S 核糖体的 50S 亚基，对肽基转移酶有活性，抑制肽键的形成。

Dichlorophen (DDM) 是一种抗微生物剂，对绦虫，原生动物，真菌和细菌具有活性，通过增加肠道内容物的清除，消除肠道中的绦虫感染。

Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) 是一种对抗原生动物感染的硝基咪唑类药物。

β-Ocimene 是从许多植物物种的叶子和花中大量释放的挥发性物质，是多种传粉媒介的多面引诱剂，具有抗利什曼原虫活性，可抑制 M。 persicae 的生长。

Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.

L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 µM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response

Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively.

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

4-Amino-L-phenylalanine (4APhe) 是 TcCA 激活剂，可用于研究原生动物病原体感染。

GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation. GW837016X extended life of treated mice by 50%, compared to untreated controls. At the cellular level, GW837016X inhibited mitosis and cytokinesis in T. brucei.

NEU617 is an inhibitor of the growth of protozoan parasites, against T. brucei bloodstream proliferation.

PF00349412 is a selective inhibitor of protozoan protein N-​myristoyltransferases. Inhibition of N-​myristoyltransferase has been validated pre-​clin. as a target for the treatment of fungal and trypanosome infections, using species-​specific inhibitors.

FFK29 is a synthetic class II HDACi (Histone deacetylase inhibitors) which have have recently emerged as novel therapeutic options for treating various protozoan and parasitic diseases. While these HDACi demonstrated a negligible effect on the viability of mature cysts, Acanthamoeba encystation was significantly inhibited by these HDACi. In conclusion, these synthetic HDACi demonstrated potent amoebicidal effects and inhibited the growth and encystation of Acanthamoeba, thus highlighting their enormous potential for further development.

Imidocarb dipropionate 是一种抗原虫剂，对寄生虫 B. bovis 的 IC50为 87 μg mL。

ELQ-596是一种喹诺酮衍生物，具有抗菌活性，可作用于包括红细胞内寄生虫Plasmodium和Babesia在内的多种原生动物寄生虫。ELQ-596可减轻免疫缺陷小鼠的巴贝斯虫病。

ELQ-650是一种喹诺酮衍生物，对多种原生动物寄生虫（包括红细胞内寄生虫Plasmodium和Babesia）具有抗菌活性，可减轻免疫缺陷小鼠的巴贝斯虫病。

3-Deoxyaphidicolin 是一种植物毒素，对莴苣幼苗根部生长有抑制作用，并对利什曼原虫 Leishmania major 和 Leishmania braziliensis 展示抑制活性。

Hydroxy Dimetridazole-d3 是 Hydroxy Dimetridazole 的氘代化合物。Hydroxy Dimetridazole 的 CAS 号为 936-05-0。Hydroxy Dimetridazole 是Dimetridazol的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物，可用于对抗原生动物感染。

Dimetridazole-d3 是 Dimetridazole 的氘代化合物。Dimetridazole 的 CAS 号为 551-92-8。Dmetridazole 是一种对抗原生动物感染的硝基咪唑类药物。