prostaglandin i2

AZ-1355是一种新型二苯并恶西平衍生物，具有降脂效果。

15(R)-Prostaglandin I2 (15(R)-PGI2) sodium 是 Epoprostenol (Prostaglandin I2) sodium 的 15(R) 立体异构体。

Epoprostenol sodium (Prostaglandin I2 sodium salt) 是短效血管稀释剂，是一种合成前列环素，可用于研究肺动脉高压和充血性心力衰竭。

MRE-269 (ACT-333679) 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。

Iloprost (Ciloprost) 是前列腺素 I2 的稳定合成类似物，是一种血小板聚集和血管扩张抑制剂，可用于研究心血管疾病。

Prostaglandin I2 是一种不稳定的前列腺素，借助“I 前列腺素类物质”(IP) 受体来抑制血小板聚集并促进肺血管床的血管扩张。AFP 07 是一种 7,7-二氟前列环素衍生物，充当 IP 受体的选择性高效激动剂 (Ki=0.561 nM)。在EP受体上，AFP 07 的亲和力相对较弱，对 EP1-3 的 Ki 值大于 100 nM，对 EP4 的 Ki 值大于 10 nM。16(R)-AFP 07 free acid 是其差向异构体，其在生物学特性上（尤其是通过 IP 和 EP 受体）仍需进一步研究。

ONO 1301 是一种前列环素（PGI2）拟似物，并具有抑制血栓烷 A2 合成酶的活性。在 DBTC 诱导的慢性胰腺炎模型中，ONO 1301 通过其直接作用及诱导肝细胞生长因子（HGF）产生、抑制单核细胞活性，从而抑制胰腺纤维化。ONO 1301 还可通过 IP 受体信号促进 HGF 合成并升高细胞内 cAMP 水平，凸显ONO 1301 在纤维化疾病和炎症研究中的治疗潜力。

15-keto Treprostinil is an impurity found in treprostinil , which is a stable analog of prostaglandin I2 with a longer plasma half-life. Formulations containing treprostinil are used for the treatment of primary pulmonary hypertension.

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).

Clinprost is a Vasodilator (peripheral), Platelet aggregation inhibitor, and Prostaglandin I2 receptor agonist

CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid, or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively. It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells (EC50s = 13 and 9.5 µM, respectively). CP21 (200 mg/kg) increases the excretion of iron, but not copper, zinc, calcium, or magnesium, in rabbits.