ph-11

PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.

VS-II-173 is a novel potent Pim1 and Pim3 inhibitor, selectively inducing AML cell death.

SI-2 hydrochloride (EPH 116 hydrochloride) 是 SRC-3 的抑制剂，诱导乳腺癌细胞死亡的 IC50 值为 3-20 nM。SI-2 hydrochloride 具有良好的药代动力学特征和改善的毒性，以及可接受的口服可用性。

Phosphostim, a gamma9deta2 T lymphocytes agonist, is used potentially for the treatment of renal cell carcinoma, HCV infection.

Azodicarbonamide是一个能通过针对nucleocapsid CCHC domains来抑制HIV-1及多种逆转录病毒的核衣壳抑制剂。在标准细胞抗病毒测试中，该化合物能够抑制HIV-1RF引起的CEM-SS细胞病变，其EC50值为38 µM。

ICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of ICAAc increases. It displays excitation/emission maxima of 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively. The absorption maximum of ICAAc decreases with increasing pH. It displays absorption/emission maxima of 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. ICAAc can be used for live cell applications. |1. Nagy, M., Racz, D., Nagy, Z.L., et al. Amino-isocyanoacridines: Novel, tunable solvatochromic fluorophores as phystiological pH probes. Sci. Rep. 9, 8250 (2019).

monoMICAAc is a solvatochromic fluorescent pH probe.1 As the polarity of the solvent increases, the emission wavelength of monoMICAAc increases. It displays excitation/emission maxima of 425/491, 437/515, and 472/554 nm in hexane, dioxane, and water, respectively. The absorption maximum of monoMICAAc decreases with increasing pH. It displays absorbance/emission maxima of 475/553 and 446/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. monoMICAAc can be used for live cell fluorescent applications. |1. Nagy, M., Racz, D., Nagy, Z.L., et al. Amino-isocyanoacridines: Novel, tunable solvatochromic fluorophores as phystiological pH probes. Sci. Rep. 9, 8250 (2019).

CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 |1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors. Bioorg. Med. Chem. 17(22), 7816-7822 (2009).|2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, and small molecule inhibitors - A STING in the tale of ENPP1. Molecules 24(22), E4192 (2019).|3. Ghani, U., and Ullah, N. New potent inhibitors of tyrosinase: Novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site. Bioorg. Med. Chem. 18(11), 4042-4048 (2010).|4. Amtul, Z., Rasheed, M., Choudhary, M.I., et al. Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles/thiadiazoles and triazoles. Biochem. Biophys. Res. Commun. 319(3), 1053-1063 (2004).

Ald-Ph-amido-PEG11-NH-Boc is a non-cleavable 11-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs).

Ald-Ph-amido-PEG11-C2-NH2 is an 11-unit polyethylene glycol (PEG) linker that is non-cleavable. It is specifically designed for use in the synthesis of antibody-drug conjugates (ADCs).

AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) 是一种从乳香中分离的天然成分，是新颖的 Nrf2 的活化剂。

TRITC-dextran MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) 是一种分子量为 500 kD 的荧光染料，其激发波长为 555 nm。由于在广泛的 pH 范围（pH 2–11）下保持稳定并且具有抗光漂白的特性，TRITC-dextran MW 500000 常用于药物输送。

TRITC-dextran MW 20000 是一种分子量为 20 kD 的荧光染料，其激发波长为 555 nm。TRITC-dextran MW 20000 可以穿透血管，用于标记血浆以实现脉管系统的可视化。由于 TRITC 在宽 pH 范围（pH 2–11）内稳定且具有抗光漂白特性，TRITC-dextran MW 20000 常用于药物输送。

TRITC-dextran MW 70000 是一种分子量为 70 kD 的荧光染料，其激发波长为 555 nm。由于 TRITC 在 pH 2–11 的范围内具有稳定性并且抗光漂白，因此 TRITC-dextran MW 70000 常用于药物输送。

TRITC-dextran MW 40000 是一种分子量为 40 kD 的荧光染料，激发波长为 555 nm，具有血管穿透性，能够标记血浆以可视化脉管系统。同时，TRITC-dextran MW 40000 可用于药物输送，这得益于TRITC 在广泛的 pH 范围（即 pH 2–11）内保持稳定性，并具抗光漂白特性。

TRITC-dextran MW 150000 是一种分子量为150 kD的荧光染料，激发波长为555 nm。由于其在 pH 2–11 的广泛范围内稳定且具有抗光漂白性，TRITC-dextran MW 150000 被应用于药物输送。

TRITC-dextran MW 2000000是一种分子量为 2000 kD 的荧光染料。其激发波长为 555 nm。由于 TRITC 在 pH 2–11 的广泛范围内保持稳定并具有抗光漂白性，因此 TRITC-dextran MW 2000000 常用于药物输送。

TRITC-dextran MW 4000 是一种分子量为 4 kD 的荧光染料，其激发波长为 555 nm。该化合物具有血管穿透性，可用于标记血浆以实现脉管系统的可视化。此外，TRITC-dextran MW 4000 在药物输送中具有应用价值，因为 TRITC 在 pH 2–11 的范围内具有稳定性，且抗光漂白性良好。