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TargetMol产品目录中 "

pde-4-in-4

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  • 抑制剂&激动剂
    15
    TargetMol | Inhibitors_Agonists
  • 同位素
    1
    TargetMol | Isotope_Products
  • PDE4-IN-4
    PDE4-IN-4
    T392101793069-00-7
    PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of pulmonary diseases.
    • ¥ 10600
    6-8周
    规格
    数量
  • PDE IV-IN-1
    T10201225100-12-9In house
    PDE IV-IN-1 是一种有效的磷酸二酯酶4 (PDE4)抑制剂,具有抗炎活性,可用于治疗哮喘,慢性阻塞性肺病和其他炎症性疾病,是研究抑郁症的潜在化合物。
    • ¥ 3670
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • RS-25344
    T9239152814-89-6
    RS-25344 是一种有效的选择性磷酸二酯酶 (PDE) 4 抑制剂。它在体外抑制嗜酸性粒细胞趋化性并增加精子的进行性运动。
    • ¥ 780
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Zardaverine
    BY 290, B 84290, 扎达维林
    T17284101975-10-4
    Zardaverine (BY 290) 是一种可口服且具有选择性和有效性的 PDE3 4 抑制剂 ,具有支气管扩张活性和抗肝癌活性。Zardaverine 在血小板中的作用是通过PDE III同工酶介导,可用于研究急性肾衰竭呵呵慢性气流阻塞。
    • ¥ 196
    In stock
    规格
    数量
  • PDE4B/D-IN-4
    T201092
    PDE4B D-IN-4,亦称为compound 4p,是一种针对PDE-4B与PDE-4D的高效抑制剂,其IC50值分别达到5.50 nM与6.81 nM。该化合物作用后可提升细胞内的cAMP水平。
    • 待询
    规格
    数量
  • GPD-1116
    T201696690690-72-3
    GPD-1116 是一种口服活性的PDE4和PDE1磷酸二酯酶抑制剂,能有效减少烟雾导致的肺细胞凋亡。此化合物在多种动物疾病模型中显示出疗效,如肺气肿、急性肺损伤、慢性阻塞性肺病 (COPD)、哮喘及肺动脉高压。
    • 待询
    10-14周
    规格
    数量
  • Eggmanone
    T22077505068-32-6
    Eggmanone (EGM1) 是一种有效的、选择性的磷酸二酯酶 4(PDE4)拮抗剂,对 PDE4D3 的 IC50为 72 nM。Eggmanone 对 PDE4D3 的选择性大约是其他 PDE 的 40-50 倍。Eggmanone 通过选择性拮抗 PDE4 发挥 Hh 抑制作用,导致蛋白激酶 A 激活和随后的 Hh 阻断。
    • 待估
    35日内发货
    规格
    数量
  • CBS-3595
    CBS3595
    T26964908380-97-2
    CBS-3595 is a potent and dual Inhibitor of p38α MAPK PDE-4 with a superior profile regarding its anti-inflammatory effects. CBS-3595 features moderate inhibition of p38α MAPK and PDE-4 in the higher nanomolar range in combination with excellent kinetic pr
    • ¥ 11700
    6-8周
    规格
    数量
  • PDE4-IN-3
    PDE4-IN-3
    T403562755687-49-9
    PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.
    • ¥ 10600
    6-8周
    规格
    数量
  • Theophylline sodium glycinate
    T605118000-10-0
    Theophylline (1,3-Dimethylxanthine) sodium glycinate 是一种有效的磷酸二酯酶 (PDE) 抑制剂,可抑制 PDE3 活性以松弛气道平滑肌。Theophylline sodium glycinate 可用于研究哮喘和慢性阻塞性肺疾病 (COPD) 。Theophylline sodium glycinate 也是一种腺苷受体拮抗剂和组蛋白脱乙酰酶 (HDAC) 激活剂。 Theophylline sodium glycinate 通过增加 IL-10 和抑制 NF-κB 的核输入而具有抗炎活性。Theophyllin sodium glycinate 可诱导细胞凋亡。
    • ¥ 10600
    6-8周
    规格
    数量
  • CC-1088
    T69223467421-06-3
    CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).
    • ¥ 10600
    6-8周
    规格
    数量
  • (E/Z)-Ensifentrine
    T69491298680-25-8
    (E Z)-Ensifentrine is a potent and selective PDE3 4 inhibitor. (E Z)-Ensifentrine acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever, and is currently in clinical trials.
    • ¥ 11700
    6-8周
    规格
    数量
  • Cipamfylline
    T70974132210-43-6
    Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human models of acute and chronic irritant contact dermatitis. The outcome of the study revealed that cipamfylline was more effective than vehicle in treating atopic dermatitis, but less effective than a group II steroid, hydrocortisone-17-butyrate both in the treatment of atopic dermatitis and irritant contact dermatitis. The absorption of cipamfylline and the subsequent systemic exposure might be the reason why further clinical studies with higher doses of cipamfylline have not been published.
    • ¥ 10600
    6-8周
    规格
    数量
  • Z21090
    T876552992690-71-6
    Z21090 (ZL40) 是一种有效的PDE4抑制剂,IC50值为37.4 nM,具有口服生物利用度。在酒精相关疾病研究中发挥重要作用。
    • 待询
    10-14周
    规格
    数量
  • Vardenafil-d5
    伐地那非-d5
    TMIJ-01141189685-70-8
    Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。
    • 待询
    20日内发货
    规格
    数量
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