p 33

CGP 33304 is a dual leukotriene receptor antagonist and phospholipase A2 inhibitor. It prevents hypoxia secondary to bronchial constriction induced by leukotriene in a shocking state.

KV1.3 channel antagonist

CEP-33779是一种新型，选择性，有口服活性的JAK2抑制剂，IC50值为1.8±0.6 nM。

LCMV gp33-41 acetate 是淋巴细胞性脉络丛脑膜炎病毒的序列，受主要组织相容性复合体 I 类 H-2Db 限制，呈递给细胞毒性 T 淋巴细胞。

GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with an SC50 of 344 nM. GP33-41 Epitope is a strong agonist of CD8 T cells.

SMP-33693为一种抗体-药物偶联物（Antibody-Drug Conjugates (ADCs)），其有效载荷（payload）稳定性高，显示出对卵巢癌、胃癌及乳腺癌肿瘤的体内抑制作用。

Human IgG1(K214R L234F L235E P331S)-kappa Isotype control 是 Human IgG1(K214R L234F L235E P331S)-kappa 抗体的同型对照。

SLU-PP-332 是一种泛雌激素受体相关受体 (ERR) 激动剂，其对 ERRα, ERRβ 以及 ERRγ 具有很高的亲和力，EC50 值分别为 98、230 以及 430 nM。SLUPP-332 可增强骨骼肌细胞系的线粒体功能和细胞呼吸，增加 IIa 型氧化骨骼肌纤维并增强了运动耐力。SLU-PP-332 具有研究代谢性疾病以及肌肉功能改善的潜力，可能用于改善代谢紊乱和衰老。

5HPP-33 is an microtubule-stabilizer with the properties of antiproliferative and antimitotic.

CP-339818 is of great value in immune system studies, where the loss of Kv1.4 makes it functionally selective to Kv1.3, and it has shown inhibition of T cell activation.

LCMV gp33-41 (TFA)是一种带有羧基延伸的11-aa长肽，作为淋巴细胞脉络丛脑膜炎病毒序列，在MHC I类H-2Db分子的限制下，能够被呈递给细胞毒性T淋巴细胞。

Human GIP(3-30), amide 是一种在体外具有高亲和力的人 GIP 受体拮抗剂。

GP(33-41) TFA 是一种由 9 个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的序列。GP(33-41) TFA 能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子，SC50值为 344 nM。

LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1].

CP-331684 is a bio-active chemical.

OSIP339391 is a A2BAR antagonist.

Detorubicin is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.

Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。

LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is a sequence of lymphocytic choriomeningitis virus restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes. This is the H-2Db restricted epitope derived from the lymphocytic.

PF-00337210 is an orally available ATP-competitive inhibitor of the vascular endothelial growth factor receptor type 2 (VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, the VEGFR2 tyrosine kinase inhibitor PF-00337210 selectively binds to VEGFR2 and prevents its phosphorylation which may result in an inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and may eventually cause tumor cell death. VEGFR2, a receptor tyrosine kinase, is frequently overexpressed by a variety of tumor types.

Human GALP (3-32) (Galanin-like peptide (3-32)) 是一种高效的galanin receptor激动剂。在竞争性结合实验中，该化合物对GalR1 (IC50=33 nM) 及GalR2 (IC50=15 nM) 表现出强烈亲和力。此外，human GALP (3-32) 显著增加了转染GalR2 (EC50=360 nM) 的 SH-SY5Y细胞的胞外酸化速率。

Detorubicin Free Base is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.

Human IgG1(P331S E430G)-kappa Isotype control 是 Human IgG1(P331S E430G)-kappa 抗体的同型对照。

Antimalarial agent 33 (compound 5g) 显示针对红细胞期和肝期疟原虫的抗活性，特别是对 K1 恶性疟原虫株，其EC50为1.1 μM。Antimalarial agent 33 还展示出提升的微粒体稳定性（T1 2=29分钟），并且对原代肝细胞未表现出明显的细胞毒效应。