no

Hydrangenol 是一种天然产物，可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 是口服有效的抗光老化化合物，可以预防皱纹的形成。Hydrangenol 可以降低 MMP 和炎症细胞因子的表达，增加保湿因子和抗氧化基因的水平。

NOC-5 是一种 NO 供体，诱导气道松弛，浓度依赖性地引发 10 μM DAF-2 荧光。

Kaempferol-7-O-β-D-glucopyranoside (Kaempferol-7-O-D-glucopyranoside) 是一种黄酮类化合物，分离自Malus pumilaMill. 花朵中，具有抗氧化、抗炎和促凝血作用。

Sanggenon D (Sanggenone D) 是来自桑白皮的小分子化合物，是GABA（A）受体调节剂，具有抗氧化抗菌活性，抑制乳腺癌细胞增殖，通过调节脂肪酸生物合成系统来抑制金黄色葡萄球菌的生长。

Sappanone A 是一种高异黄烷酮，通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。

2',3,5,6',7-Pentahydroxyflavanone (3,5,7,2',6'-Pentahydroxyflavanone) 是从黄芩的根中分离得到的天然产物。

5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的，具有抗炎活性。

8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.

Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

Celaphanol A shows moderate inhibition in both NF-κB activation and nitric oxide production, suggests that it is a possible inhibitor of the NF-kappaB pathway and has antiinflammatory activity.

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.

Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone exerts anti-obesity effect through do

Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.

(+)-Hannokinol and MESO-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM.

Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.

Kobophenol A是一种来源于植物的低聚二苯乙烯(oligostilbene)类天然产物，具有多靶点生物活性。研究表明，Kobophenol A可能干扰ACE2与SARS-CoV-2刺突蛋白RBD的结合，从而在病毒入侵过程中发挥潜在抑制作用；此外，Kobophenol A亦被报道对Protein kinase C具有一定调节或抑制活性。

Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac

Narchinol B shows inhibitory activity against LPS-induced NO production.

Nortrachelogenin ((-)-Wikstromol) 可从 Partrinia scabiosaefolia 提取得到，具有抗真菌活性，可诱导膜破坏和半胱天冬酶依赖性细胞凋亡.

Odorine and odorinol inhibit both the initiation and promotion stages of two-stage skin carcinogenesis. (+)-Odorinol exhibits strong antiviral activity against Ranikhet disease virus (RVD) in chick embryo.

Oxyphyllenone A can inhibit the NO production in lipopolysaccharide-activated macrophages.

Piscidinol A is toxic against the 4T1 and HEp2 cancer cell lines, the IC50 of 8.0 ± 0.03 and 8.4 ± 0.01 uM, respectively. It can inhibit NO production in mouse peritoneal macrophages with inhibitory ratios ranging from 39.8±7.7 to 68.2±4.5%.

Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 and inhibit NO an

Sanggenon N shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 23.45 ± 4.72 uM. It inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages.