neuron-2

Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂，对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期，也抑制 hERG，IC50为 6.3 μM。

1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。

Safrole oxide 可显著抑制神经元细胞生长并诱导细胞凋亡。Safrole oxide 可上调 COX-2、IL-8 及 ROS 水平，并伴随 NF-κB 的核转位，Safrole oxide 可能诱导内皮细胞转分化为功能性类神经元细胞。

FP802 是一种口服的强效TwinF界面抑制剂，能够破坏并解除NMDAR/TRPM4死亡复合物的毒性。在5xFAD阿尔茨海默病 (AD) 小鼠模型中，FP802 展示出显著的神经保护作用，有效防止认知功能下降、保持神经元结构的完整性、减少β-淀粉样蛋白斑块的形成，并减轻线粒体损伤。在肌萎缩侧索硬化 (ALS) 小鼠模型中，这种化合物可阻止运动神经元的丢失、降低血清神经丝轻链 (NfL) 水平、增强运动功能，并延长小鼠的寿命。FP802 可用于阿尔茨海默病和肌萎缩侧索硬化症的相关研究[1][2]。

SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA).

16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices. 1.Hoffstrom, B.G., Kaplan, A., Letso, R., et al.Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteinsNat. Chem. Biol.6(12)900-906(2010)

Palmitic acid-1-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid (T2908) is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid (T2908) is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6

Photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm. Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331 PMID:18311146 |Polosukhina et al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271 PMID:22841312 |Banghart et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID:19882609

Rasagiline-13C3 (mesylate) is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo (ED50= 0.1 mg/kg).1It reduces cerebral edema in a mouse model of traumatic brain injury.2Rasagiline (0.1 mg/kg)reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP)in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease.3Formulations containing rasagiline have been used in the treatment of Parkinson's disease.

TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro. Loucif et al (2018) GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 175 2272 PMID:29150838

Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是：抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活，进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。

3'-Methoxypuerarin 是一种提取自葛根中的异黄酮，具有神经元保护作用。

Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。

PA22-2 (free acid) (Cys-Laminin A chain 2091-2108) 为促进神经突生长和神经元样过程形成的多肽。该化合物适用于人腺样囊性癌细胞培养和肽功能化磷脂双层制备^[3]。

KPZ560作为HDAC1和HDAC2的有效抑制剂，在IC50数值上分别达到12 nM 和68 nM 。此化合物能提升小鼠颗粒神经元树突的棘密度，同时也能抑制MCF乳腺癌细胞系的生长。

3'-Methoxypuerarin (Standard) 是 3'-Methoxypuerarin 的标准品。适用于定量分析、质量控制及生化实验等相关研究。3'-Methoxypuerarin 是一种提取自葛根中的异黄酮，具有神经元保护作用。

APGW-amide 是一种神经肽，能够控制假雄性化结构的生长，并促进 Haliotis asinina 的身体生长。它可以抑制 Achatina 神经元类型，同时调节神经活性化合物在神经元上诱发的电流。APGW-amide 还能够在 Fura-2/AM 负载的 PC12 细胞中诱导 [Ca2+]i 的快速升高，被用于神经系统研究。

IUB0271 (acyl-GIP) hydrochloride 是一种脂肪酰化的长效葡萄糖依赖性促胰岛素多肽 (GIP)。IUB0271 hydrochloride 能增强 DIO 小鼠模型中下丘脑摄食中枢的 cFos 神经元活性，并在 CNS-GIPR 信号的作用下减少小鼠体重、食物摄入和血糖。IUB0271 hydrochloride 可用于 2 型糖尿病 (T2DM) 和肥胖症的研究。