n-acylethanolamines

Pentadecanoyl ethanolamide，一种N-acylethanolamine的内源性脂质酰胺衍生物，对电击休克的小鼠展现出抗惊厥效果，同时无明显毒性。

N-Acylethanolamines (NAEs) are lipid-derived signaling compounds, with arachidonoyl ethanolamide functioning as an endogenous cannabinoid (CB) that activates CB1 and CB2 receptors. Among these, Palmitoleoyl Ethanolamide (POEA) is synthesized endogenously from palmitoleic acid. Notably, unlike arachidonoyl ethanolamide and palmitoyl ethanolamide, POEA lacks antinociceptive effects in the formalin-evoked pain model.

PDP-EA 是脂肪酸酰胺水解酶 (FAAH) 的激活剂，可增强 FAAH 的酰胺水解酶活性。

Linoleoyl ethanolamide phosphate is an intermediate in the biosynthesis of linoleoyl ethanolamide, generated through phospholipase C-mediated hydrolysis of N-acylphosphatidylethanolamine. Linoleoyl ethanolamide phosphate, along with other endogenous N-acylethanolamines, is thought to regulate food intake by selectively prolonging feeding latency and post-meal interval [Linoleoyl Ethanolamide Phosphate].

LEI-401 是一种可穿过血脑屏障且具有选择性和有效性的 NAPE-PLD 抑制剂(IC50：27 nM)。LEI-401 降低自由活动小鼠脑内n -酰基乙醇胺(NAEs)含量，可调节小鼠情绪行为。