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Search Results for " myeloperoxidase "

Targets Recommended: Glutathione Peroxidase

29

抑制剂 & 化合物

5

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T26389	4-POBN NSC-640,NSC640,4-Aminobenzohydrazide,4-氨基苯甲酰肼,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH	Glutathione Peroxidase	Metabolism
	4-POBN (Myeloperoxidase Inhibitor 1) 是一种有效且不可逆的髓过氧化物酶抑制剂 (IC50 = 0.3 µM)。 4-POBN 可用于亚急性中风的研究。
T5463	Verdiperstat AZD3241,AZD 3241	Glutathione Peroxidase	Metabolism
	Verdiperstat (AZD 3241) 是一种不可逆的、选择性的、口服具有活力的髓过氧化物酶 (myeloperoxidase) 抑制剂，IC50=630 nM，可用于研究大脑神经退行性疾病。
T4090	PF-06282999	Glutathione Peroxidase	Metabolism
	PF06282999 是选择性的髓过氧物酶 (myeloperoxidase) 抑制剂，用于研究心血管疾病。
T5340	MPO-IN-28	Glutathione Peroxidase	Metabolism
	MPO-IN-28 是髓过氧化物酶 (MPO) 抑制剂，IC50=44 nM。
T9416	Dansylglycine	Others	Others
	Dansylglycine 是一种荧光探针，用于特异性测定髓过氧化物酶和嗜酸性粒细胞过氧化物酶的卤化活性。
T61028	Mitiperstat AZD4831	Glutathione Peroxidase	Metabolism
	Mitiperstat 是一种强效的骨髓过氧化物酶（MPO）抑制剂。Mitiperstat 对预防如心力衰竭和冠状动脉疾病类的心血管疾病有很好的效果。
T14379	AZD5904	Glutathione Peroxidase	Metabolism
	AZD5904 是一种不可逆的人髓过氧化物酶选择性抑制剂，其IC50=140 nM，在小鼠和大鼠中也具有相似的效力。
TP2334	PMX 53 acetate(219639-75-5 free base)	Complement System	Immunology/Inflammation
	PMX 53 acetate(219639-75-5 free base) 是一种有效的口服活性 CD88 (C5aR) 拮抗剂 (IC50: 20 nM)，抑制 C5a 诱导的中性粒细胞髓过氧化物酶释放和趋化性，IC50 值分别为 22 nM 和 75 nM。 PMX-53 也是 Mas 相关基因 2 (MrgX2) 的激动剂。
T38063	N-Acetyl lysyltyrosylcysteine amide	Glutathione Peroxidase	Metabolism
	N-Acetyl lysyltyrosylcysteine amide 是一种无毒的髓过氧化物酶 (MPO) 三肽抑制剂，具有有效性，可逆性和特异性。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成，蛋白质硝化和 LDL 氧化。N-Acetyl lysyltyrosylcysteine amide 可用于研究支气管发育不良。
T25510	HX1 HX 1,HX-1
	HX1 is a potent reversible myeloperoxidase (MPO) inhibitor.
T69110	Aseanostatin P5
	Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes.
T38063L	N-Acetyl lysyltyrosylcysteine amide acetate N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)	Glutathione Peroxidase	Metabolism
	N-Acetyl lysyltyrosylcysteine amide acetate 是一种有效且特异性的髓过氧化物酶 (MPO) 三肽抑制剂。 N-Acetyl lysyltyrosylcysteine amide acetate 抑制 MPO 依赖性次氯酸的生成、蛋白质硝化和 LDL 氧化反应。 N-Acetyl lysyltyrosylcysteine amide acetate 可减少中风后大脑中的神经元损伤并保护脑组织和神经功能。
T38914	MPO-IN-3
	MPO-IN-3, a powerful inhibitor of myeloperoxidase (MPO), is described as such in example 191 of WO2013068875A1. MPO, a heme-containing enzyme, is classified under the peroxidase superfamily.
T69287	NAA-004
	NAA-004, also known as APAZA, has been shown to significantly inhibit toxin A-induced myeloperoxidase activity, luminal fluid accumulation, and structural damage to the colon in instances of toxin A-induced colitis.
T61711	COX-2-IN-14
	COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory activity, COX-2-IN-14 effectively reduces ear edema and myeloperoxidase (MPO) activity in mice [1].
T8223	Avacopan CCX168	Complement System	Immunology/Inflammation
	Avacopan (CCX168) 是一种口服小分子 C5aR (IC50: 0.1 nM.) 拮抗剂，可阻断 C5a 的作用并防止 AAV 小鼠模型中抗髓过氧化物酶抗体诱导的 GN 发展。
T40137	MPO-IN-1
	MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-1 effectively inhibits both enzymes. Furthermore, it exhibits remarkable MPO inhibitory activity in an acute inflammation mouse model.
T36235	5-Chlorouracil
	5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. ...
T62347	MPO-IN-5
	MPO-IN-5 是一种有效的、不可逆的 MPO (髓过氧化物酶) 抑制剂。MPO-IN-5 能够抑制 MPO 过氧化作用 (IC50: 0.22 μM)，也能够抑制 hERG 结合 (IC50: 2.8 μM)。MPO-IN-5 显示出快速的抑制动力学，酶失活率 (kinact/Ki) 为 23000 M 1s 1。
T38384	Nexinhib20
	Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflamma...
T73659	HLF1-11
	HLF1-11，一种人乳铁蛋白衍生肽，是一种广谱抗菌剂。HLF1-11 抑制MPO(human) 的活性。HLF1-11 还使GM-CSF 驱动的单核细胞向巨噬细胞分化，并增强其免疫反应。
T60281	MPO-IN-4
	MPO-IN-4 (compound 12) 是一种有效的选择性髓过氧化物酶 (MPO) 抑制剂，IC50为 25 nM。MPO-IN-4对甲状腺过氧化物酶(TPO)也显示抑制作用，IC50为2.2 μM。MPO-IN-4 对甲基鸟嘌呤甲基转移酶 (MGMT) 没有影响。
T37270	9(E),11(E)-12-nitro Conjugated Linoleic Acid
	9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma. 1.Woodcock, S.R., Salvato...
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T36830	9-Nitrooleate
	Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 9-Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-nitrooleate (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in a...
T83669	PMX-53 TFA AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53
	PMX-53是一种大环型补体5a (C5a) 类肽模拟物及C5a受体的拮抗剂（IC50 = 0.3 µM）。它能抑制C5a诱导的人类分离性多形核白细胞（PMNs）中的髓过氧化物酶（MPO）分泌。在大鼠腹膜亚瑟斯反应模型中，PMX-53（10 mg/kg, p.o.）能够抑制血管渗漏、多形核白细胞浸润以及腹膜TNF-α和IL-6的产生。在3-硝基丙酸（3-NP）诱导的亨廷顿病大鼠模型中，它能减少体重损失和厌食，抑制纹状体退化。PMX-53（3 mg/kg）还能在ApoE-/-小鼠中减小动脉粥样硬化斑块大小和脂质含量。
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...
T36660	Olsalazine-13C6 Olsalazine-13C6
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...

化合物

Cat.No: T26389

Synonym: NSC-640,NSC640,4-Aminobenzohydrazide,4-氨基苯甲酰肼,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH

Target: Glutathione Peroxidase

Cat.No: T5463

Synonym: AZD3241,AZD 3241

Target: Glutathione Peroxidase

Cat.No: T4090

Target: Glutathione Peroxidase

Cat.No: T5340

Target: Glutathione Peroxidase

Cat.No: T9416

Target: Others

Cat.No: T61028

Synonym: AZD4831

Target: Glutathione Peroxidase

Cat.No: T14379

Target: Glutathione Peroxidase

PMX 53 acetate(219639-75-5 free base)

Cat.No: TP2334

Target: Complement System

N-Acetyl lysyltyrosylcysteine amide

Cat.No: T38063

Target: Glutathione Peroxidase

Cat.No: T25510

Synonym: HX 1,HX-1

Aseanostatin P5

Cat.No: T69110

N-Acetyl lysyltyrosylcysteine amide acetate

Cat.No: T38063L

Synonym: N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)

Target: Glutathione Peroxidase

Cat.No: T38914

Cat.No: T69287

Cat.No: T61711

Cat.No: T8223

Synonym: CCX168

Target: Complement System

Cat.No: T40137

Cat.No: T36235

Cat.No: T62347

Cat.No: T38384

Cat.No: T73659

Cat.No: T60281

9(E),11(E)-12-nitro Conjugated Linoleic Acid

Cat.No: T37270

2-chloro Palmitic Acid

Cat.No: T36221

Cat.No: T36830

Cat.No: T83669

Synonym: AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53

O-Desmethyl-N-deschlorobenzoyl Indomethacin

Cat.No: T36418

Olsalazine-13C6

Cat.No: T36660

Synonym: Olsalazine-13C6

Cat.No: T35881

Cat. No.	Product Name	Target	Signaling Pathways
T5280	3-Chloro-L-Tyrosine 3-氯-L-酪氨酸,3-Chlorotyrosine,Chlorotyrosine	Others; Endogenous Metabolite	Metabolism; Others
	3-Chloro-L-Tyrosine (Chlorotyrosine) 是一种髓过氧化物酶催化氧化的特异性标志物，在从人动脉粥样硬化内膜分离的低密度脂蛋白中显著升高。
TJS0338	4-Methylesculetin 4-Methyl-6,7-dihydroxycoumarin,6,7-二羟基-4-甲基香豆素,Methylesculetin,4-甲基七叶亭	Antioxidant; Glutathione Peroxidase	Metabolism; oxidation-reduction
	4-Methylesculetin (Methylesculetin) 是口服具有活力的天然香豆素衍生物，有抗氧化、抗炎特性。它可抑制myeloperoxidase 的特性，抑制 IL-6 的水平
TN4303	Isokaempferide	ATPase; Potassium Channel; Calcium Channel; TNF; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea.
T75618	Sorbifolin
	Sorbifolin 是一种黄酮苷，可以从蝉翼豆Pterogyne nitens 中分离出来。 Sorbifolin 具有髓过氧化物酶抑制和自由基清除活性。Sorbifolin 也是一种MPO 抑制剂，IC50值为 19.2 nM。
T37770	Taurohyodeoxycholic acid
	Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi...

天然产物

3-Chloro-L-Tyrosine

Cat.No: T5280

Synonym: 3-氯-L-酪氨酸,3-Chlorotyrosine,Chlorotyrosine

Target: Others, Endogenous Metabolite

4-Methylesculetin

Cat.No: TJS0338

Synonym: 4-Methyl-6,7-dihydroxycoumarin,6,7-二羟基-4-甲基香豆素,Methylesculetin,4-甲基七叶亭

Target: Antioxidant, Glutathione Peroxidase

Cat.No: TN4303

Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor

Cat.No: T75618

Taurohyodeoxycholic acid

Cat.No: T37770

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05252	Myeloperoxidase/MPO Protein, Human, Recombinant (His) myeloperoxidase	Human	HEK293
	MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important enzyme, which is one of the components of the antibacterial system in neutrophils and monocytes. MPO participates in the inflammatory response in multiple locations in the body, including the mammary glands. Myeloperoxidase (MPO), a specific polymorphonuclear leukocyte enzyme, has ...
TMPJ-00833	MPO Protein, Mouse, Recombinant (His) MPO,Myeloperoxidase	Mouse	Human Cells
	Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride, bromide, and iodide to multiple reactive species. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. Modification of ApoB100, as well as the lipid and cholesterol components of LDL and HDL, promotes the development of a...

重组蛋白

Myeloperoxidase/MPO Protein, Human, Recombinant (His)

Cat.No: TMPY-05252

Species: Human

Expression System: HEK293

MPO Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00833

Species: Mouse

Expression System: Human Cells

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