mosaic

Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) 是一种具有亚甲二氧基活性的天然分子，与反式肉桂酸结构相似，可作为选择性反式肉桂酸 4-羟化酶的灭活剂。

Yadanziolide A 来源于 Brucea javanica 干燥的种子。它具有强的抗病毒作用，能够抗烟草花叶病毒(IC50:5.5 μM)。它具有抗肿瘤活性。

Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells. Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells. It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.

(±)-Phrymarolin II is a promising new class of plant virus (tobacco mosaic virus) inhibitors.

Chaparrinone 是一种来自Ailanthus altissima（Mill.）的苦木素类化合物，具有抗疟、抗肿瘤和抗病毒活性，可用于研究烟草花叶病毒感染和SARS 病毒感染。

7-Deoxy-trans-dihydronarciclasine 作为生物碱，担任烟草花叶病毒（TMV）抑制剂（IC50: 1.80 μM），亦具有抗神经炎症作用，能够降低Tg2576小鼠大脑皮质中Aβ与APP水平。

Herbimycin B 是安莎霉素类抗生素，作为Src家族激酶抑制剂，对大多数单子叶和双子叶植物具有除草作用，并能抑制烟草花叶病毒 (TMV)、HeLa 细胞及艾氏细胞的活性。

Methyl 4-Hydroxyphenylacetate has potent inhibitory activity against tobacco mosaic virus (TMV).

Citrusin B exhibits moderate in vitro inhibitory effect on tobacco mosaic virus replication with IC50 values 0.26 mmol L⁻1.