lipid droplet

Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物，可抑制脂肪形成，降低PPARγ的表达，诱导SIRT1易位和表达。

Beauveriolide III 是一种存在于 Beauveria 属真菌中的环肽类化合物，可抑制脂滴形成（3-10 μM 时）及胆固醇合成（IC50=0.41 μM）。该化合物还能抑制酰基辅酶 A:胆固醇酰基转移酶（ACAT）活性（IC50=5.5 μM），并在 Ldlr-/- 和 ApoE-/- 小鼠模型中减少动脉粥样硬化斑块大小（25-50 mg/kg）。

Bafilomycin B1是一种发现于Streptomyces gresuis的大环内酯类抗生素，具有神经保护作用和V-ATPase抑制活性，还能够抑制LDL诱导的脂滴积聚。

Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979J. Antibiot. (Tokyo)52(1)1-6(1999) 2.Namatame, I., Tomoda, H., Ishibashi, S., et al.Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophagesProc. Nat. Acad. Sci. USA101(3)737-742(2004)