lipid 5

Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity.

LNP Lipid-5 (化合物 Lipid 2) 是一种可电离的氨基脂质。LNP Lipid-5 适用于脂质纳米颗粒 (LNP) 的制备。

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) 是一种TLR激动剂，用于作为疫苗佐剂，以提高疫苗的免疫原性。

Lipid TD5是一种可离子化的阳离子脂质(pKa = 7.3)，用于生成用于体内和体外递送mRNA的脂质纳米颗粒(LNPs)。含有Lipid TD5的LNPs在主要小鼠星形胶质细胞中，以依赖于5-羟色胺(5-HT)受体亚型1A的方式进行内吞摄取。将含有Lipid TD5的LNPs鞘内给药后，能够在小鼠中选择性运输至大脑，而较少到达肝脏和脾脏。

Lipid A (14:0(5)-cyclopropyl17:0(1)) diammonium 是一种脂质，作为佐剂并具有免疫刺激特性。

Lipid A (14:0(5)-iso15:0(1)) diammonium，一种脂质佐剂，具有免疫刺激特性。

Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W140 in supplemental material). It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

98N12-5 是一种新型的可电离脂质，用于siRNA 在体内高效传递到肝脏。

cis-13,16,19-Docosatrienoic acid methyl ester 是二十二碳三烯酸的酯形式，这种酸是罕见的 ω-3 脂肪酸，在正常的磷脂多不饱和脂肪酸库中难以检测到。该化合物以 5 μM 的浓度能够抑制 [3H]-LTB4 与猪嗜中性粒细胞的结合。相比游离酸，二十二碳三烯酸甲酯具有更好的脂溶性，在某些制剂中可能更为理想。

LNP Lipid-6 (化合物 Lipid 5) 是一种可电离脂质 (氨基脂质)，可用于制备脂质纳米颗粒 (LNP)。

(3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate 是一种月桂酸酯衍生物，含有二甲氧基三苯甲基 (DMT) 保护基和 3-吡咯烷醇结构。该化合物可应用于寡核苷酸修饰或作为脂溶性递送载体的研究。

2′-Hydroxy-5′-nitrohexadecanamide 是一种溶酶体水解酶 (Lysosomal hydrolase) 的抑制剂，其结构包含十五酸和末端硝基苯酚的脂质。通过抑制溶酶体水解酶的活性，它会导致细胞内脂质的积累。此外，2′-Hydroxy-5′-nitrohexadecanamide 还可以用来合成用于测定鞘磷脂酶活性的显色底物。