lh-2

LH2 peptide 是一种具有细胞穿透性的 pH 响应性肽二聚体，其氨基酸序列为 LHHLCHLLHHLCHLAG。在弱酸性环境（如肿瘤微环境）中，由于组氨酸残基的质子化 (pKa约为 6)，该多肽可以增强肿瘤细胞内摄取。将 LH2 peptide 与抗癌剂紫杉醇共轭形成的复合物 PTX-LH2，在皮下乳腺肿瘤模型中表现出比单独使用紫杉醇更强的肿瘤抑制效果。LH2 peptide 有潜力成为抗癌研究中的递送载体。

LH2-051是一种通过DAT-CDK9-TFEB通路激活溶酶体生物合成和清除Aβ聚集体的溶酶体增强先导化合物。在小鼠模型中，LH2-051显示出优良的药代动力学性质，具备改善阿兹海默症症状的潜力。

PLH2058- 是一种可用于调节、限制或抑制AVIL（advillin）表达的化合物，可用于治疗癌症。[1]

Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) 是一种具有潜在抗肿瘤活性的原癌基因 c-Met (HGFR) 的口服生物可利用抑制剂。

LH-21 是一种有效的体内中性大麻素 CB1受体拮抗剂。LH-21 会导致剂量依赖性进食抑制，减少肥胖 Zucker 大鼠的食物摄入和体重增加。

Sephadex LH 20 is a suitable medium for the isolation of natural compounds found in various sources, including red wine and pigments, aiding in their purification and extraction processes.

Spexin acetate(1370290-58-6 free base) 是一种有效的甘丙肽受体 2 3 (GAL2 GAL3) 激动剂（EC50 值分别为 45.7 和 112.2 nM）。对甘丙肽受体 1 没有显着的活性。抑制脂肪细胞对长链脂肪酸的摄取并减少饮食诱导的肥胖小鼠和大鼠的食物消耗。减少金鱼的 LH 分泌。在体内表现出抗焦虑作用。

Myr-Arf1(2–17) 为一种肌氨酸化多肽,主要功能是模仿 Arf1 蛋白在细胞膜上的定位及其功能.该化合物同时应用于探索卵泡黄体生成素 绒毛膜促性腺激素受体 (LH CGR) 的脱敏作用机理研究.

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. DCVC effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures. [1]. Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6. [2]. Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65. [3]. Yoo HS, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78(1):32-49.

Spexin TFA, a potent agonist for galanin receptor 2 3 (GAL2 GAL3) with EC50 values of 45.7 and 112.2 nM respectively, shows no significant activity towards galanin receptor 1. As an endogenous peptide promoting satiety, it reduces long chain fatty acid uptake by adipocytes and lowers food consumption in diet-induced obese mice and rats. Additionally, it moderates LH secretion in goldfish and demonstrates anxiolytic effects in vivo.

Prolactin-Releasing Peptide (1-31) (rat) 通过减少禁食诱导的大鼠食物摄入，有效提升血浆LH、FSH及睾酮水平。

Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽，其作用可在体外实现。

NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm). Tritiated NBI-42902 binds with high affinity (K(d) = 0.19 nm) to a single class of binding sites and can be displaced by a range of peptide and nonpeptide GnRH receptor ligands. In vitro experiments demonstrate that NBI-42902 is a potent functional, competitive antagonist of GnRH stimulated IP accumulation, Ca(2+) flux, and ERK1 2 activation. It did not stimulate histamine release from rat peritoneal mast cells. Finally, it is effective in lowering serum LH in castrated male macaques after oral administration. Overall, these data provide a benchmark of pharmacological characteristics required for a nonpeptide GnRH antagonist to effectively suppress gonadotropins in humans and suggest that NBI-42902 may have clinical utility as an oral agent for suppression of the hypothalamic-pituitary-gonadal axis. (source: Endocrinology. 2007 Feb;148(2):857-67. Epub 2006 Nov 9.)

Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-54 (10-1,000 nM) inhibits insulin secretion from isolated mouse pancreatic β-cells in the presence of 2.8 mM, but not 11.1 mM, glucose.2 Kisspeptin-54 (1-5 nmol, i.c.v.) increases serum levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in mice, an effect which is reversed by the gonadotropin releasing hormone (GNRH) antagonist acycline.3References1. Kotani, M., Detheux, M., Vandenbogaerde, A.L., et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276(37), 34631-34636 (2001).2. Vikman, J., and Ahrén, B. Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets. Diabetes Obes. Metab. 11(Suppl 4), 197-201 (2009).3. Gottsch, M.L., Cunningham, M.J., Smith, J.T., et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145(9), 4073-4077 (2004). Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-54 (10-1,000 nM) inhibits insulin secretion from isolated mouse pancreatic β-cells in the presence of 2.8 mM, but not 11.1 mM, glucose.2 Kisspeptin-54 (1-5 nmol, i.c.v.) increases serum levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in mice, an effect which is reversed by the gonadotropin releasing hormone (GNRH) antagonist acycline.3 References1. Kotani, M., Detheux, M., Vandenbogaerde, A.L., et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276(37), 34631-34636 (2001).2. Vikman, J., and Ahrén, B. Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets. Diabetes Obes. Metab. 11(Suppl 4), 197-201 (2009).3. Gottsch, M.L., Cunningham, M.J., Smith, J.T., et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145(9), 4073-4077 (2004).

Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment. Formulations containing abarelix have previously been used in the treatment of advanced prostate cancer.

Potent galanin receptor 2 3 (GAL2 GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreas

GnRH Associated Peptide (GAP) (25-53), human 是来源于人的促性腺激素释放激素相关肽（GAP）的一个特定片段，具体为第25至第53位氨基酸（hGAP-25-53）。本片段可用作免疫原，用以产生含有MC-1、MC-2和MC-3等抗体的抗血清。GAP通过其内含的三个氨基酸加工位点，能与黄体生成素释放激素（LH-RH）序列进行有效连接。

Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) 是下丘脑神经肽，在控制生殖功能中起关键作用。

pGlu-His-Pro-Gly-NH2（Glp-His-Pro-Gly-NH2）为含四氨基酸肽类化合物，可激发促性腺激素、黄体生成素（LH）与促卵泡激素（FSH）释放。

LH-RH II (chicken) 为家鸡下丘脑黄体生成素释放激素(LHRH)两种形式之一，亦为哺乳动物LHRH的结构变体。该化合物促进家鸡促性腺激素释放。