l 345

L 345 is a bioactive chemical.

6-Glucosyl-3,4',5,7-tetrahydroxyflavanone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T130743。

Benzamide, N-(decahydro-2-methyl-5-isoquinolyl)-3,4,5-trimethoxy-, cis- is a bioactive chemical.

Benzamide, N-(decahydro-2-methyl-5-isoquinolyl)-3,4,5-trimethoxy-, trans- is a bioactive chemical.

Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.[2] Reference：[1]. Maianti, J.P., McFedries, A., Foda, Z.H., et al. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511(7507), 94-98 (2014).[2]. Bannister, T.D., Wang, H., Abdul-Hay, S.O., et al. ML345, a small-molecule inhibitor of the insulin-degrading enzyme (IDE). 1 R03 DA024888-01 (MLSCN cycle 6), 1-41 (2014).

Preterramide C is a fungal metabolite that has been found inA. terreus.1It is active againstS. aureus(MIC = 52.4 μM) but notE. aerogenes,P. aeruginosa, orC. albicans(MICs = >100 μM for all).2Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50value of 0.1 μg/ml.3It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50= 5.48 μM).

(3S,4R,5S)-Methyl 3,4,5,6-tetrahydroxy-2-oxohexanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65295，CAS号为 3031-98-9。

Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.

Ethyl 3,4,5-trimethoxybenzoate is a natural product derived from Rauvolfia verticillata.

L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitorsBioorg. Med. Chem. Lett.24(1)61-64(2014)