l 345

L 345 is a bioactive chemical.

ML-345是一种选择性和有效的IDE(胰岛素降解酶)抑制剂（IC50=188 nM），靶向IDE中的半胱氨酸残基Cys819，可用于研究2型糖尿病和阿尔茨海默病。

Preterramide C is a fungal metabolite that has been found inA. terreus.1It is active againstS. aureus(MIC = 52.4 μM) but notE. aerogenes,P. aeruginosa, orC. albicans(MICs = >100 μM for all).2Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50value of 0.1 μg/ml.3It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50= 5.48 μM).

(3S,4R,5S)-Methyl 3,4,5,6-tetrahydroxy-2-oxohexanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65295，CAS号为 3031-98-9。

UniPR129 是一种高选择性、可透过细胞膜的竞争性Eph/ephrin拮抗剂，属于石胆酸衍生的L-高色氨酸缀合物。UniPR129 可抑制EphA2与ephrin-A1的相互作用，IC₅₀=945 nM，Ki=345 nM。UniPR129 可抑制HUVEC细胞血管生成，IC₅₀=5.2 μM。UniPR129具有抗肿瘤和神经保护作用，可用于癌症和神经系统疾病的研究。

L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitorsBioorg. Med. Chem. Lett.24(1)61-64(2014)